Echinacea purpurea-derived homogeneous polysaccharide exerts anti-tumor efficacy via facilitating M1 macrophage polarization

文献类型： 外文期刊

第一作者： Ren, Wenkai

作者： Ren, Wenkai;Ban, Junfeng;Xia, Yaoyao;Zhou, Fang;Yuan, Caihong;Jia, Huanhua;Huang, Hailan;Jiang, Mingmin;Liang, Minjian;Li, Zhaodong;Wu, Hong;Ban, Junfeng;Yuan, Caihong;Jia, Huanhua;Huang, Hailan;Jiang, Mingmin;Liang, Minjian;Wu, Hong;Ban, Junfeng;Zhou, Fang;Jia, Huanhua;Yuan, Youyong;Yin, Yulong

作者机构：

期刊名称：INNOVATION （ 影响因子：32.1； 五年影响因子：32.1 ）

ISSN： 2666-6758

年卷期： 2023 年 4 卷 2 期

页码：

收录情况： SCI

摘要： Echinacea purpurea modulates tumor progression, but the underlying mechanism is poorly defined. We isolated and purified a novel homoge-neous polysaccharide from E. purpurea (EPPA), which was shown to be an arabinogalactan with a mean molecular mass (Mr) of 3.8 3 104 Da and with a-(1-> 5)-L-Arabinan as the backbone and a-L-Araf-(1->, ->6)-b-D-Galp-(1->, and ->4)-a-D-GalpA-(1-> as the side chains. Interestingly, oral administration of EPPA suppresses tumor progression in vivo and shapes the immune cell profile (e.g., facilitating M1 macrophages) in tumor micro -environment by single-cell RNA sequencing (scRNA-seq) analysis. More importantly, EPPA activates the inflammasome through a phagocytosis-dependent mechanism and rewires transcriptomic and metabolic profile, thereby potentiating M1 macrophage polarization. Collectively, we propose that EPPA supplementation could function as an adjuvant therapeutic strat-egy for tumor suppression.

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