Extraction, Structure and Immunoregulatory Activity of Low Molecular Weight Polysaccharide from Dendrobium officinale

文献类型： 外文期刊

第一作者： Sun, Su-Jun

作者： Sun, Su-Jun;Deng, Peng;Peng, Chun-E;Mao, Long-Fei;Peng, Li-Zeng;Ji, Hai-Yu

作者机构：

关键词： D; officinale; low-molecular weight polysaccharide; structural characteristics; immunoregulatory activity

期刊名称：POLYMERS （ 影响因子：4.967； 五年影响因子：5.063 ）

ISSN：

年卷期： 2022 年 14 卷 14 期

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收录情况： SCI

摘要： The ethanol precipitation method has been widely-used for Dendrobium officinale polysaccharides preparation. However, the alcohol-soluble fractions have always been ignored, which causes significant wastes of resources and energies. In this study, the extraction, physicochemical properties, and immune regulation activity of an edible D. officinale polysaccharide (DOPs) isolated from the supernatant after 75% ethanol precipitation were systematically investigated. The structural characteristics determination results showed that DOPs was mainly composed of glucose and mannose at a molar ratio of 1.00:5.78 with an average molecular weight of 4.56 x 10(3) Da, which was made up of alpha-(1,3)-Glcp as the main skeleton, and the alpha-(1,4)-Glcp and beta-(1,4)-Manp as the branches. Subsequently, the cyclophosphamide (CTX)-induced immunosuppressive mice model was established, and the results demonstrated that DOPs could dose-dependently protect the immune organs against CTX damage, improve the immune cells activities, and promote the immune-related cytokines (IL-2, IFN-gamma and TNF-alpha) secretions. Furthermore, DOPs treatment also effectively enhanced the antioxidant enzymes levels (SOD, GSH-Px) in sera and livers, therefore weakening the oxidative damage of CTX-treated mice. Considering these above data, DOPs presented great potential to be explored as a natural antioxidant and supplement for functional foods.

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