Exploring the effects of perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) on silkworm from the insights of metabolome
文献类型： 外文期刊
第一作者： Zhang, Xing
作者： Zhang, Xing;Kong, Yifei;He, Zihan;Yu, Wenbin;Shao, Wenjing;Gong, Chengliang;Hu, Xiaolong;Zhou, Wenlin
作者机构：
关键词： PFOA; TBBPA; Silkworm; Metabolite; Exposure
期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.1； 五年影响因子：6.4 ）
ISSN： 0147-6513
年卷期： 2025 年 289 卷
页码：
收录情况： SCI
摘要： Perfluorooctanoic acid (PFOA) and tetrabromobisphenol A (TBBP-A) are emerging environmental contaminants with recognized potential health and ecological risks. This study investigated the effects of PFOA and TBBP-A exposure on the global of metabolites of silkworm gut with GC-MS metabolomics. Our results revealed distinct metabolic alterations in silkworms exposed to PFOA and TBBP-A, highlighting their differential impacts on silkworm health and productivity. Exposure to these chemicals significantly altered metabolic profiles, leading to disruptions in pathways related to lipid, carbohydrate, and amino acid metabolism. These findings suggest that PFOA and TBBP-A disrupt crucial metabolic processes in silkworms, indicating potential toxicity and prompting further investigation into their effects on human health and the environment. Ongoing research is crucial to develop safer alternatives and mitigate the risks associated with these persistent contaminants.
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