Identification and Pathogenicity Evaluation of a Novel Reassortant Infectious Bursal Disease Virus (Genotype A2dB3)

文献类型： 外文期刊

第一作者： Wang, Yulong

作者： Wang, Yulong;Jiang, Nan;Fan, Linjin;Niu, Xinxin;Zhang, Wenying;Huang, Mengmeng;Gao, Li;Li, Kai;Gao, Yulong;Liu, Changjun;Cui, Hongyu;Liu, Aijing;Pan, Qing;Zhang, Yanping;Wang, Xiaomei;Qi, Xiaole;Wang, Yulong;Jiang, Nan;Fan, Linjin;Niu, Xinxin;Zhang, Wenying;Huang, Mengmeng;Gao, Li;Gao, Yulong;Cui, Hongyu;Liu, Aijing;Wang, Xiaomei;Qi, Xiaole;Wang, Xiaomei

作者机构：

关键词： infectious bursal disease virus; novel variant strain; genome; segment reassortment; pathogenicity

期刊名称：VIRUSES-BASEL （ 影响因子：5.048； 五年影响因子：5.127 ）

ISSN：

年卷期： 2021 年 13 卷 9 期

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收录情况： SCI

摘要： Infectious bursal disease virus (IBDV) is a non-enveloped, bi-segmented double-stranded RNA virus and the causative agent of a poultry immunosuppressive disease known as infectious bursal disease (IBD). The novel variant IBDV (nVarIBDV) recently posed a great threat to the development of the poultry industry. In this study, we identified a novel segment-reassortant IBDV strain, IBDV-JS19-14701 (Genotype A2dB3). Phylogenic analysis showed that Segments A and B of IBDV-JS19-14701 were derived from emerging nVarIBDV (Genotype A2dB1) and long-prevalent HLJ0504-like strains (Genotype A3B3) in China, respectively. The pathogenicity of IBDV-JS19-14701 was further evaluated via animal experiments. IBDV-JS19-14701 exhibited a similar virulence to chickens with the nVarIBDV. The identification of this reassortment event is beneficial for understanding the epidemiology of nVarIBDV and will contribute to the efficient prevention and control of IBD.

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