Designing a synthetic moss genome using GenoDesigner

文献类型： 外文期刊

第一作者： Yu, Wenfei

作者： Yu, Wenfei;Zhao, Shijun;Zhao, Qiao;Ma, Yixing;Huang, Xiaoluo;Dai, Junbiao;Yu, Wenfei;Zhang, Shuo;Zhao, Shijun;Wang, Ying;Jiao, Yuling;Ma, Yixing;Huang, Xiaoluo;Qian, Wenfeng;Dai, Junbiao;Zhang, Shuo;Chen, Lian-ge;Jiao, Yuling;Qian, Wenfeng;Cao, Jie;Ye, Hao;Yan, Jianbin;Dai, Junbiao;Mo, Beixin;Dai, Junbiao;Jiao, Yuling;Jiao, Yuling

作者机构：

期刊名称：NATURE PLANTS （ 影响因子：18.0； 五年影响因子：18.6 ）

ISSN： 2055-026X

年卷期： 2024 年

页码：

收录情况： SCI

摘要： The de novo synthesis of genomes has made unprecedented progress and achieved milestones, particularly in bacteria and yeast. However, the process of synthesizing a multicellular plant genome has not progressed at the same pace, due to the complexity of multicellular plant genomes, technical difficulties associated with large genome size and structure, and the intricacies of gene regulation and expression in plants. Here we outline the bottom-up design principles for the de novo synthesis of the Physcomitrium patens (that is, earthmoss) genome. To facilitate international collaboration and accessibility, we have developed and launched a public online design platform called GenoDesigner. This platform offers an intuitive graphical interface enabling users to efficiently manipulate extensive genome sequences, even up to the gigabase level. This tool is poised to greatly expedite the synthesis of the P. patens genome, offering an essential reference and roadmap for the synthesis of plant genomes. The authors present the design principles of a synthetic earthmoss (Physcomitrium patens) genome. To aid future genome design projects, they also develop GenoDesigner, a software package that provides users with an intuitive graphical interface to efficiently manipulate genomic sequences.

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