Signal transducer and activator of transcription 3 (Stat3) expression and activation in rat uterus during early pregnancy

文献类型： 外文期刊

第一作者： Teng, CB

作者： Teng, CB;Diao, HL;Ma, H;Cong, J;Yu, H;Ma, XH;Xu, LB;Yang, ZM

作者机构：

关键词： Leukemia inhibitory factor;Endometrial stromal cells;Lif-receptor;Blastocyst implantation;Targeted disruption;Mouse uterus;Oncostatin-m;In-vitro;Gene;Decidualization

期刊名称：REPRODUCTION （ 影响因子：3.906； 五年影响因子：4.51 ）

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收录情况： SCI

摘要： Signal transducer and activator of transcription 3 (Stat3), a member of the Stat family, is specifically activated during mouse embryo implantation. The aim of this study was to investigate the expression, activation and regulation of Stat3 in rat uterus during early pregnancy, pseudo pregnancy, delayed implantation and artificial decidualization. Stat3 mRNA was highly expressed in the luminal epithelium on day 5 and in the luminal epithelium and underlying stromal cells at implantation sites on day 6 of pregnancy. There was a strong level of Stat3 protein expression and phosphorylation in the stromal cells near the lumen and in the luminal epithelium on day 5 of pregnancy, which was similar to day 5 of pseudopregnancy. In the afternoon of day 6, the strong level of Stat3 phosphorylation was detected only in the luminal epithelium. Stat3 was highly expressed and activated in the decidual cells from days 7 to 9 of pregnancy and under artificial decidualization in the present study. Our results suggest that the strong level of Stat3 activation in the luminal epithelium and underlying stromal cells during the preimplantation period may be important for establishing uterine receptivity as in mice, and the high level of Stat3 expression and activation in decidual cells may play a role during decidualization.

分类号： TS8

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