beta-catenin has potential effects on the expression, subcellular localization, and release of high mobility group box 1 during bovine herpesvirus 1 productive infection in MDBK cell culture

文献类型： 外文期刊

第一作者： Fan, Wenqing

作者： Fan, Wenqing;Ding, Xiuyan;Zhu, Liqian;Fan, Wenqing;Ding, Xiuyan;Zhu, Liqian;Fan, Wenqing;Ding, Xiuyan;Zhu, Liqian;Yuan, Weifeng

作者机构：

关键词： BoHV-1; HMGB1; β -catenin; mitochondria

期刊名称：VIRULENCE （ 影响因子：5.542； 五年影响因子：5.946 ）

ISSN： 2150-5594

年卷期： 2021 年 12 卷 1 期

页码：

收录情况： SCI

摘要： High mobility group box 1 (HMGB1), a ubiquitous DNA-binding protein, can be released into extracellular space and function as a strong proinflammatory cytokine, which plays critical roles in the pathogenesis of various inflammatory diseases. Here, we showed that BoHV-1 productive infection in MDBK cells at later stage significantly increases HMGB1 mRNA expression and the protein release, but decreases the steady-state protein levels. Virus infection increases accumulation of HMGB1 protein in both nucleus and mitochondria, and relocalizes nuclear HMGB1 to assemble in highlighted foci via a confocal microscope assay. Interestingly, beta-catenin-specific inhibitor iCRT14 is able to increase HMGB1 transcription and the protein release, and subcellular translocation in virus-infected cells. HMGB1-specific inhibitor, glycyrrhizin, could differentially affect virus gene transcription such as, the viral regulatory protein bICP0, bICP4 and bICP22, as well as glycoprotein gD. In summary, our data provides a novel mechanism that beta-catenin signaling may regulate inflammatory response via affecting HMGB1 signaling.

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