Spatially confining copper nanoclusters in porous ZrO2 for fluorescence/colorimetry/smartphone triple-mode detection of metoprolol tartrate

文献类型： 外文期刊

第一作者： Li, Songrui

作者： Li, Songrui;Huang, Zhenzhen;Jia, Qiong;Zhang, Huifeng

作者机构：

关键词： PorousZrO2; Copper nanoclusters; Spatial confinement; Metoprolol tartrate; Triple-mode detection

期刊名称：BIOSENSORS & BIOELECTRONICS （ 影响因子：12.6； 五年影响因子：10.8 ）

ISSN： 0956-5663

年卷期： 2023 年 231 卷

页码：

收录情况： SCI

摘要： Sensitive detection of metoprolol tartrate (MPT) is extremely urgent in the therapy of cardiovascular diseases to guarantee the curative effectiveness. Herein, porous ZrO2 was first employed as a matrix to spatially confine CuNCs (ZrO2@CuNCs), which simultaneously ameliorated the emission intensity and stability of CuNCs. Benefiting from the inner filter effect (IFE) and dynamic quenching effect (DQE) between ZrO2@CuNCs and AuNPs and the color fading of AuNPs induced by MPT, fluorometric and colorimetric methods for simple and sensitive determination of MPT were proposed. Besides, to meet the demand of convenient detection of MPT, a portable sensing platform was constructed including a dark box produced by a 3D printer and a smartphone. This method was further employed to determine MPT in human serum and urine samples with satisfactory results with the triple mode. This work is the first attempt to fabricate a multi-mode optical and portable sensor for MPT detection, which provides a novel approach for point-of-care monitoring of drugs in the treatment of diseases.

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