Terbium-triggered aggregation-induced emission of bimetallic nanoclusters for anticancer drugs sensing via the inner filter effect

文献类型： 外文期刊

第一作者： Mu, Jin

作者： Mu, Jin;Huang, Zhenzhen;Jia, Qiong;Zhang, Huifeng

作者机构：

关键词： Fluorescence; Aggregation -induced emission; Bimetallic nanoclusters; Anticancer drugs; Inner filter effect

期刊名称：SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY （ 影响因子：4.4； 五年影响因子：3.9 ）

ISSN： 1386-1425

年卷期： 2023 年 291 卷

页码：

收录情况： SCI

摘要： The development of accurate and sensitive detection methods of anticancer drugs is of significant importance because they play vital roles in biological systems. In recent years, bimetallic nanoclusters (BMNCs) incorporating the advantages of two metals have gained more and more attention, and can be widely applied in sensing applications. In this work, for the first time, we designed a sensing platform based on terbium ion (Tb3+) triggered aggregation-induced emission (AIE) of BMNCs. Tb3+ hybrid glutathione (GS) protected Ag/Cu nanoclusters ((Tb3+)@GS-AgCuNCs) were facilely fabricated according to the complexation reaction between Tb3+ and the carboxyl group of GS. Due to the inner filter effect (IFE), the fluorescence of Tb3+@GS-AgCuNCs decreased significantly in the presence of anticancer drugs with 6-thioguanine and methotrexate as representatives. In addition, the sensing platform was applied to monitor 6-thioguanine and methotrexate in real serum samples, indicating that it has great potential in anticancer drugs related applications.

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