Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone from agarwood of Aquilaria crassna Pierre ex Lecomte in Laos
文献类型： 外文期刊
第一作者： Zhao, Yang-Mei
作者： Zhao, Yang-Mei;Yang, Li;Kong, Fan-Dong;Dong, Wen-Hua;Li, Wei;Chen, Hui-Qin;Wang, Hao;Cai, Cai-Hong;Gai, Cui-Juan;Mei, Wen-Li;Dai, Hao-Fu;Yang, Li;Kong, Fan-Dong;Dong, Wen-Hua;Li, Wei;Chen, Hui-Qin;Wang, Hao;Cai, Cai-Hong;Gai, Cui-Juan;Mei, Wen-Li;Dai, Hao-Fu;Zhao, Yang-Mei
作者机构：
关键词： Agarwood; Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae); 5; 6; 7; 8-tetrahydro-2-(2-phenylethyl)chromone; cytotoxicity
期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）
ISSN： 1478-6419
年卷期：
页码：
收录情况： SCI
摘要： Three new 5,6,7,8-tetrahydro-2-(2-phenylethyl)chromones and one new dimeric 2-(2-phenylethyl)chromone were isolated from the agarwood of Aquilaria crassna Pierre ex Lecomte in Laos. The structures of the isolates were elucidated by spectroscopic methods, and their configurations were determined via ROESY correlations, (3)J(H-H) coupling constants analyses, comparisons of chemical shifts and specific rotations with known compounds, and ECD calculation in the case of 1. Compounds 1?4 were evaluated for their cytotoxicity. Compounds 1 and 2 exhibited weak cytotoxicity toward HeLa cell line (IC50: 49.8???1.2??M) and K562 cell line (IC50: 42.66???0.47??M), respectively.
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