Host miR-148 regulates a macrophage-mediated immune response during Schistosoma japonicum infection

文献类型： 外文期刊

第一作者： Giri, Bikash Ranjan

作者： Giri, Bikash Ranjan;Cheng, Guofeng

作者机构：

关键词： Extracellular vesicle; microRNA cargo; miR-148a; Schistosoma japonicum; Macrophage

期刊名称：INTERNATIONAL JOURNAL FOR PARASITOLOGY （ 影响因子：3.981； 五年影响因子：4.214 ）

ISSN： 0020-7519

年卷期： 2019 年 49 卷 13-14 期

页码：

收录情况： SCI

摘要： Extracellular vesicles are critical regulators of host-parasite interactions. We previously demonstrated that Schistosoma japonicum EVs contain a remarkably high abundance of host miR-148a. Here, we characterised the abundance of miR-148a in circulation, in peripheral immune cells, and in plasma EVs of S. japonicum-infected mice. The results suggested the high abundance of miR-148a in macrophages to be likely linked to S. japonicum EVs. Additionally, miR-148a was found to target PTEN through the PI3K/AKT pathway to regulate cytokine production in macrophages. Consequently, our findings suggest that high abundance of miR-148a in macrophages may be associated with S. japonicum EVs, and regulate the host immune response during schistosome infection. (C) 2019 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.

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