New antifungal cycloheximide epimers produced by Streptomyces sp. YG7

文献类型: 外文期刊

第一作者: Pan, Jie-Ming

作者: Pan, Jie-Ming;Chen, Hui-Qin;Wang, Hao;Yang, Li;Cai, Cai-Hong;Mi, Cheng-Neng;Dai, Hao-Fu;Mei, Wen-Li;Pan, Jie-Ming;Mi, Cheng-Neng;Tan, Zhi-Qiong;Pan, Jie-Ming

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关键词: Cycloheximide derivative; Streptomyces sp; antifungal activity

期刊名称:JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH ( 影响因子:1.569; 五年影响因子:1.598 )

ISSN: 1028-6020

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收录情况: SCI

摘要: A couple of new cycloheximide epimers, 13(alpha)-acetoxy-anhydroisoheximide (1) and 13(beta)-acetoxy-anhydroisoheximide (2), together with six known compounds (3-8), were obtained from the cultures of Streptomyces sp. YG7. The structures were elucidated based on a comprehensive spectroscopic data analysis including 1D and 2D NMR, as well as HRESIMS, and by comparison with the literature. The X-ray crystal analysis of 1 further confirmed the structure. All the compounds were tested for antifungal activity. Compounds 1, 2 and 5-8 showed moderate Canidia albicans inhibitory activity, while 5 and 6 presented moderate Pyricularia oryzae inhibitory activity. [GRAPHICS] .

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