Development of Water-Compatible Molecularly Imprinted Polymers Based on Functionalized beta-Cyclodextrin for Controlled Release of Atropine

文献类型： 外文期刊

第一作者： He, Yahui

作者： He, Yahui;Yohannes, Woldemariam Kalekristos;Khan, Majid;He, Yahui;Zeng, Shaomei;She, Yongxin;Abd El-Aty, A. M.;Abd El-Aty, A. M.;Abd El-Aty, A. M.;Hacimuftuoglu, Ahmet

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关键词： molecularly imprinted polymers; beta-cyclodextrin; water-compatible; Atropine; controlled release

期刊名称：POLYMERS （ 影响因子：4.329； 五年影响因子：4.493 ）

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年卷期： 2020 年 12 卷 1 期

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收录情况： SCI

摘要： Herein, a novel method for molecularly imprinted polymers (MIPs) using methacrylic acid functionalized beta-cyclodextrin (MAA-beta-CD) monomer is presented, which was designed as a potential water-compatible composite for the controlled release of atropine (ATP). The molecularly imprinted microspheres with pH-sensitive characteristics were fabricated using thermally-initiated precipitation polymerization, employing ATP as a template molecule. The effects of different compounds and concentrations of cross-linking agents were systematically investigated. Uniform microspheres were obtained when the ratio between ATP, MAA-beta-CD, and trimethylolpropane trimethacrylate (TRIM) was 1:4:20 (mol/mol/mol) in polymerization system. The ATP loading equilibrium data was best suited to the Freundlich and Langmuir isotherm models. The in vitro drug release study was assessed under simulated oral administration conditions (pH 1.5 and 7.4). The potential usefulness of MIPs as drug delivery devices are much better than non-molecularly imprinted polymers (NIPs). The study shows that the prepared polymers are a pH stimuli-responsive system, which controlled the release of ATP, indicating the potential applications in the field of drug delivery.

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