Flammulina velutipes mycorrhizae dietary fiber attenuates the development of obesity via regulating lipid metabolism in high-fat diet-induced obese mice

文献类型： 外文期刊

第一作者： Jia, Fengjuan

作者： Jia, Fengjuan;Zhang, Jian;Hou, Furong;Shi, Junyan;Song, Shasha;Yang, Shifa;Jia, Fengjuan;Zhang, Jian;Hou, Furong;Shi, Junyan;Song, Shasha;Gao, Yulan;Yang, Shifa

作者机构：

关键词： Flammulina velutipes; dietary fiber; obesity; lipid metabolism; high-fat diet

期刊名称：FRONTIERS IN NUTRITION （ 影响因子：5.1； 五年影响因子：5.4 ）

ISSN： 2296-861X

年卷期： 2025 年 12 卷

页码：

收录情况： SCI

摘要： Introduction Mounting evidence has shown that Flammulina velutipes mycorrhizae dietary fiber (Fv-DF) has the potential to significantly improve health outcomes by addressing lipid metabolic disorders. However, the mechanism underlying Fv-DF in regulating liver lipid metabolism of high-fat diet (HFD)-induced obese mice still merits to be systematically elaborated.Methods Herein, we conducted a comprehensive study utilizing HFD-induced C57BL/6J mice as an obesity model to investigate the impact of Fv-DF on liver lipid accumulation.Results The study, which included an evaluation of Fv-DF on a high-fat diet (HFD)-induced obese mice, revealed that Fv-DF supplementation can effectively decrease weight gain, improve serum lipid levels, and reduce fat deposition in adipose tissues. The estimation of Fv-DF on liver tissues demonstrated that Fv-DF supplementation significantly ameliorated lipid metabolism and hepatic injury in HFD-induced obese mice. Furthermore, Fv-DF improved lipid metabolism in obese mice by modifying the abundance and related pathways of TG, PC, PE, and other lipid metabolites. Mechanistically, Fv-DF supplementation significantly suppressed the expression of lipid synthesis-related genes while promoting lipid oxidation-related genes.Discussion Collectively, the findings could inspire significant implications for Fv-DF in developing novel treatments for obesity-related metabolic disorders management.

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