文献类型： 外文期刊
第一作者： Mi, Cheng-Neng
作者： Mi, Cheng-Neng;Wang, Hao;Chen, Hui-Qin;Cai, Cai-Hong;Mei, Wen-Li;Dai, Hao-Fu;Mi, Cheng-Neng;Li, Shao-Peng
作者机构：
关键词： Swietenia macrophylla; roots; polyacetylene; cytotoxicity
期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）
ISSN： 1420-3049
年卷期： 2019 年 24 卷 7 期
页码：
收录情况： SCI
摘要： A phytochemical investigation of the roots of Swietenia macrophylla led to the isolation of seven polyacetylenes, including five new compounds (1-5) and two known ones (6-7). Their structures were elucidated by extensive spectroscopic analysis and detailed comparison with reported data. All the isolates were tested for their cytotoxicity against the human hepatocellular carcinoma cell line BEL-7402, human myeloid leukemia cell line K562, and human gastric carcinoma cell line SGC-7901. Compounds 1 and 6 showed moderate cytotoxicity against the above three human cancer cell lines with IC50 values ranging from 14.3 to 45.4 mu M. Compound 4 displayed cytotoxicity against the K562 and SGC-7901 cancer cell lines with IC50 values of 26.2 +/- 0.4 and 21.9 +/- 0.3 mu M, respectively.
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