文献类型： 外文期刊
第一作者： Guo, Dong-Sheng
作者： Guo, Dong-Sheng;Cao, Xue;Chen, Hui-Qin;Wei, Yan-Mei;Wang, Hao;Cai, Cai-Hong;Dai, Hao-Fu;Yang, Li;Mei, Wen-Li;Guo, Dong-Sheng;Cao, Xue;Chen, Hui-Qin;Wei, Yan-Mei;Wang, Hao;Cai, Cai-Hong;Dai, Hao-Fu;Yang, Li;Mei, Wen-Li
作者机构：
关键词： Dendrobium nobile; Bibenzyl; & alpha;-Glucosidase inhibition; Anti-inflammatory activity; Molecular docking
期刊名称：FITOTERAPIA （ 影响因子：3.4； 五年影响因子：3.3 ）
ISSN： 0367-326X
年卷期： 2023 年 169 卷
页码：
收录情况： SCI
摘要： Four new compounds ((+/-)-1-3), including one pair of enantiomers ((+/-)-1), along with 11 known bibenzyls (4-14) were isolated from Dendrobium nobile. The structures of the new compounds were elucidated by spectroscopic methods including 1D and 2D NMR as well as HRESIMS. The configurations of (+/-)-1 were established via the electronic circular dichroism (ECD) calculations. Compounds (+)-1 and 13 displayed pronounced a-glucosidase inhibitory activities with IC50 values of 16.7 +/- 2.3 and 13.4 +/- 0.2 mu M, respectively, which were comparable to that of genistein (IC50, 8.54 +/- 0.69 mu M). Kinetic studies revealed that (+)-1 and 13 were non-competitive inhibitors against a-glucosidase and molecular docking simulations illuminated their interactions with a-glucosidase. All the isolates were also evaluated for their anti-inflammatory activities. Compounds 4, 5, and 11 exhibited superior inhibition activity with IC50 values ranging from 9.2 to 13.8 mu M to that of quercetin (IC50, 16.3 +/- 1.1 mu M).
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