An Acidic Heteropolysaccharide Isolated from Pueraria lobata and Its Bioactivities

文献类型： 外文期刊

第一作者： Zhao, Shifan

作者： Zhao, Shifan;Xue, Hualei;Tao, Yijiong;Chen, Kai;Li, Xiao;Wang, Mi

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关键词： Pueraria lobata; polysaccharide; structure; bioactivity

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.6； 五年影响因子：6.2 ）

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年卷期： 2023 年 24 卷 7 期

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收录情况： SCI

摘要： A novel water-soluble acidic heteropolysaccharide, called PPL-1, was purified from Pueraria lobata. PPL-1 had an average molecular weight of 35 Kad, and it was composed of glucose, arabinose, galactose and galacturonic acid (6.3:0.8:0.8:2.1). In accordance with methylation and nuclear magnetic resonance analyses, PPL-1 primarily consisted of (1 -> 2)-linked alpha-Araf, (1 -> 4)-linked alpha-Glcp, (1 ->)-linked beta-Glcp, (1 -> 6)-linked alpha-Glcp, (1 -> 3,6)-linked alpha-Galp, (1 ->)-linked beta-GalpA and (1 -> 4)-linked alpha-GalpA. In terms of bioactivities, PPL-1 exhibited remarkable scavenging ability towards DPPH (1,1-Diphenyl-2-picrylhydrazyl) radicals and moderate activity by enhancing the proliferation rate of RAW 264.7 cells by approximately 30% along with the secretion of NO. This work demonstrates that PPL-1 can be a potential source of immunoenhancers and antioxidants.

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