Design and characterization of novel hybrid peptides from LFB15(W4,10), HP(2-20), and cecropin A based on structure parameters by computer-aided method

文献类型： 外文期刊

第一作者： Tian, Zi-gang

作者： Tian, Zi-gang;Dong, Tian-tang;Teng, Da;Yang, Ya-lin;Wang, Jian-hua

作者机构：

关键词： Antimicrobial peptides;Computer-aided method;Design;Structure parameters

期刊名称：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY （ 影响因子：4.813； 五年影响因子：4.697 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The increasing problem of antibiotic resistance among pathogenic bacteria requires development of new antimicrobial agents. The pivotal assets of the antimicrobial peptide include potential for rapid bactericidal activity and low propensity for resistance. The four new antimicrobial hybrid peptides were designed based on peptides LFB15(W4,10), HP(2-20), and cecropin A according to the structure-activity relationship of the amphipathic and cationic antimicrobial peptides. Their structural parameters were accessed by bioinformatics tools, and then two hybrids with the most potential candidates were synthesized. The hybrid peptide LH28 caused an increase in antibiotic activity (MIC_(50)∈=∈1.56-3.13 μM) against given bacterial strains and did not cause obvious hemolysis of rabbit erythrocytes at concentration of 3.13 μM with effective antimicrobial activity. The results demonstrate that evaluating the structural parameters could be useful for designing novel antimicrobial peptides.

分类号： Q939.9

  • 相关文献

[1]Expression and characterization of recombinant gallinacin-9 and gallinacin-8 in Escherichia coli. Ma, De-ying,Shan, An-shan,Liu, Sheng-wang,Han, Zong-xi,Li, Yi-jin.

[2]Design of an Electric Control System for Plastic Pipe Automatic Conveyor Line. Jiang, Rui,Huang, Hui,Zhang, Ying. 2012

[3]Synthesis and Antibacterial Activity of Novel Pleuromutilin Derivatives. Liu, Huixian,Xiao, Sui,Zhang, Lifang,Wang, Xiaoyang,Xue, Feiqun,Zhang, Depeng,Mu, Shuhua.

[4]Design, Synthesis, and Insecticidal Activity of 1,5-Diphenyl-1-pentanone Analogues. Kang Tieniu,Yang Xinling,Sun Yufeng,Cui Zining,Lin Yun,Rui Changhui. 2011

[5]The control system of the grinding machine is designed for the rubber tree push-type gluing knife field. Zhang Yuan,Deng Yiguo,Wang Yeqin,Wei Lijiao,Luo Shiqiao,Luo Shiqiao,Luo Shiqiao. 2017

[6]Design and construction of the national agricultural information system. Guo, Xichuan. 2007

[7]Rational design and efficient synthesis of a fluorescent-labeled jasmonate. Liu, Songbai,Fu, Yuanqing,Sang, Ruocheng,Wang, Wu-Hong,Dang, Ya-Li.

[8]Molecular identification and recombinant expression of red sea bream (Chrysophrys major) hepcidin gene. Chen, Song-Lin,Sui, Shao-Fei,Xu, Mei-Yu,Liu, Yang,Yang, Rong. 2005

[9]In vitro and in vivo characterization of a new recombinant antimicrobial peptide, MP1102, against methicillin-resistant Staphylococcus aureus. Zhang, Yong,Teng, Da,Wang, Xiumin,Mao, Ruoyu,Cao, Xintao,Hu, Xiaoyuan,Zong, Lifen,Wang, Jianhua,Zhang, Yong,Teng, Da,Wang, Xiumin,Mao, Ruoyu,Cao, Xintao,Hu, Xiaoyuan,Zong, Lifen,Wang, Jianhua.

[10]Bacterial expression of a Trichosanthes kirilowii defensin (TDEF1) and its antifungal activity on Fusarium oxysporum. Jian Gui-Liang,Zhang Ying-Tao,Ai Tie-Min.

[11]Mechanism of action of a novel recombinant peptide, MP1102, against Clostridium perfringens type C. Zong, Lifen,Teng, Da,Wang, Xiumin,Mao, Ruoyu,Yang, Na,Hao, Ya,Wang, Jianhua,Zong, Lifen,Teng, Da,Wang, Xiumin,Mao, Ruoyu,Yang, Na,Hao, Ya,Wang, Jianhua.

[12]Multimerization and fusion expression of bovine lactoferricin derivative LfcinB15-W4,10 in Escherichia coli. Tian, Zi-gang,Da Teng,Yang, Ya-lin,Luo, Jin,Feng, Xing-jun,Fan, Ying,Zhang, Fan,Wang, Jian-hua.

[13]Fusion expression of bovine lactoferricin in Escherichia coli. Feng, Xing-jun,Wang, Jian-hua,Shan, An-shan,Teng, Da,Yang, Ya-lin,Yao, Yi,Yang, Guan-pin,Shao, Yan-chun,Liu, Shuo,Zhang, Fan.

[14]EST-based in silico identification and in vitro test of antimicrobial peptides in Brassica napus. Ke, Tao,Cao, Huihui,Huang, Junyan,Dong, Caihua,Yu, Jingyin,Mao, Han,Liu, Shengyi,Ke, Tao,Wang, Xi,Niu, Qiuhong,Hui, Fengli,Huang, Junyan,Hu, Fan,Huang, Jin,Dong, Caihua,Ma, Xiangdong,Liu, Shengyi. 2015

[15]Effective Antimicrobial Activity of Plectasin-Derived Antimicrobial Peptides against Staphylococcus aureus Infection in Mammary Glands. Li, Lianbin,Gao, Yuqi,Zhao, Xin,Wang, Liangliang,Wang, Jianhua,Zhao, Xin. 2017

[16]Recombinant expression, purification, and antimicrobial activity of a novel hybrid antimicrobial peptide LFT33. Feng, Xingjun,Guo, Jiayin,Song, Xueying,Li, Jing,Xu, Wenshan,Liu, Chunlong,Li, Zhongqiu. 2012

[17]Gene Expression Profiling of Cecropin B-Resistant Haemophilus parasuis. Wang, Chunmei,Chen, Fangzhou,Hu, Han,Li, Wentao,Chen, Pin,Liu, Yingyu,Ku, Xugang,He, Qigai,Chen, Huanchun,Wang, Chunmei,Xue, Feiqun,Wang, Yang.

[18]Design and high-level expression of a hybrid antimicrobial peptide LF15-CA8 in Escherichia coli. Feng, Xing-Jun,Xing, Li-Wei,Liu, Di,Song, Xue-Ying,Li, Jing,Xu, Wen-Shan,Liu, Chun-Long,Li, Zhong-Qiu. 2014

[19]Two Novel Duck Antibacterial Peptides, Avian beta-Defensins 9 and 10, with Antimicrobial Activity (Retracted article. See vol. 23, pg. 1046, 2013). Liao, Wenyan,Wang, Ruiqin,Han, Zongxi,Liu, Shengwang,Ma Deying,Liao, Wenyan,Wang, Ruiqin. 2009

[20]In vitro and in vivo antibacterial effect of NZ2114 against Streptococcus suis type 2 infection in mice peritonitis models. Jiao, Jian,Mao, Ruoyu,Teng, Da,Wang, Xiumin,Hao, Ya,Yang, Na,Wang, Xiao,Wang, Jianhua,Jiao, Jian,Mao, Ruoyu,Teng, Da,Wang, Xiumin,Hao, Ya,Yang, Na,Wang, Xiao,Wang, Jianhua,Feng, Xingjun. 2017

作者其他论文 更多>>

微信小程序