Genome-wide association study of flowering time and grain yield traits in a worldwide collection of rice germplasm

文献类型： 外文期刊

第一作者： Huang, Xuehui

作者： Huang, Xuehui;Zhao, Yan;Li, Canyang;Wang, Ahong;Zhao, Qiang;Li, Wenjun;Guo, Yunli;Deng, Liuwei;Zhu, Chuanrang;Fan, Danlin;Lu, Yiqi;Weng, Qijun;Liu, Kunyan;Zhou, Taoying;Jing, Yufeng;Si, Lizhen;Dong, Guojun;Huang, Tao;Lu, Tingting;Feng, Qi;Han, Bin;Huang, Xuehui;Zhao, Yan;Han, Bin;Wei, Xinghua;Qian, Qian;Li, Jiayang

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期刊名称：NATURE GENETICS （ 影响因子：38.33； 五年影响因子：36.431 ）

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收录情况： SCI

摘要： A high-density haplotype map recently enabled a genome-wide association study (GWAS) in a population of indica subspecies of Chinese rice landraces. Here we extend this methodology to a larger and more diverse sample of 950 worldwide rice varieties, including the Oryza sativa indica and Oryza sativa japonica subspecies, to perform an additional GWAS. We identified a total of 32 new loci associated with flowering time and with ten grain-related traits, indicating that the larger sample increased the power to detect trait-associated variants using GWAS. To characterize various alleles and complex genetic variation, we developed an analytical framework for haplotype-based de novo assembly of the low-coverage sequencing data in rice. We identified candidate genes for 18 associated loci through detailed annotation. This study shows that the integrated approach of sequence-based GWAS and functional genome annotation has the potential to match complex traits to their causal polymorphisms in rice.

分类号： R394

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