Multifunctional Hyperbranched Glycoconjugated Polymers Based on Natural Aminoglycosides

文献类型： 外文期刊

第一作者： Chen, Mingsheng

作者： Chen, Mingsheng;Wang, Dali;Wang, Guojian;Zhu, Xinyuan;Yan, Deyue;Chen, Mingsheng;Hu, Mei;Sun, Jian

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期刊名称：BIOCONJUGATE CHEMISTRY （ 影响因子：4.774； 五年影响因子：4.91 ）

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收录情况： SCI

摘要： Multifunctional gene vectors with high trans-fection, low cytotoxicity, and good antitumor and antibacterial activities were prepared from natural aminoglycosides. Through the Michael-addition polymerization of gentamycin and N,N'-methylenebisacrylamide, cationic hyperbranched glycoconjugated polymers were synthesized, and their physical and chemical properties were analyzed by FTIR, ~1H NMR, ~(l3)C NMR, GPC, ζ-potential, and acid-base titration techniques. The cytotoxicity of these hyperbranched glycoconjugated polycations was low because of the hydrolysis of degradable glycosidic and amide linkages in acid conditions. Owing to the presence of various primary, secondary, and tertiary amines in the polymers, hyperbranched glycoconjugated polymersshowed high buffering capacity and strong DNA condensation ability, resulting in the high transfection efficiency. In the meantime, due to the introduction of natural aminoglycosides into the polymeric backbone, the resultant hyperbranched glycoconjugated polymers inhibited the growth of cancer cells and bacteria efficiently. Combining the gene transfection, antitumor, and antibacterial abilities together, the multifunctional hyperbranched glycoconjugated polymers based on natural aminoglycosides may play an important role in protecting cancer patients from bacterial infections.

分类号： Q5

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