Fragrant agarofuran and eremophilane sesquiterpenes in agarwood 'Qi-Nan' from Aquilaria sinensis

文献类型： 外文期刊

第一作者： Yang, De-Lan

作者： Yang, De-Lan;Wang, Hao;Guo, Zhi-Kai;Li, Wei;Mei, Wen-Li;Dai, Hao-Fu;Yang, De-Lan;Li, Wei

作者机构：

关键词： Qi-Nan;Agarwood;Aquilaria sinensis;Sesquiterpene;AChE inhibitory activities

期刊名称：PHYTOCHEMISTRY LETTERS （ 影响因子：1.679； 五年影响因子：1.861 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Phytochemical analysis of the high quality Chinese agarwood 'Qi-Nan' originating from Aquilaria sinensis (Lour.) Glig, led to the isolation of four fragrant sesquiterpenes, including an agarofuran 4-hydroxylbaimuxinol (1) and three eremophilanes, 7 beta-H-9(10)-ene-11,12-epoxy-8-oxoeremophilane (2), 7 alpha-H-9(10)-ene-11,12-epoxy-8-oxoeremophilane (3), neopetasane (4) Among them, compounds 1-3 were new compounds. Their structures were elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR) and MS analyses. Eremophilane sesquiterpenes 2-4 showed inhibitory activities against acetylcholinesterase with IC50 value of 274.8, 491.4, and 158.3 mu M, respectively. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

分类号： Q946

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