Histopathological and cytopathological findings in minipigs infected with Streptococcus suis serotype 2

文献类型: 外文期刊

第一作者: Xie, Chun

作者: Xie, Chun;Hou, Yi-Xuan;Zhao, Yu-Ting;Li, Cai-Ying;Su, Xue;Yue, Xiu-Wei;Yang, Wei-Jun;Yuan, Cong-Li;Cu, Li;Hua, Xiu-Guo;Yang, Zhi-Biao;Cai, Xue-Hui;Wang, Shu-Jie;Liu, Yong-Gang;Li, Cai-Ying;Li, Pei-Feng;Li, Yun-Zhang;Su, Xue;Yang, Wei-Jun

作者机构:

关键词: miniature pig;Streptococcus suis 2;experimental infection;histopathology;cytopathology.

期刊名称:BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY ( 影响因子:0.643; 五年影响因子:0.547 )

ISSN:

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收录情况: SCI

摘要: Five pathogen-free miniature pigs (minipigs) were infected with the virulent strain SH08 of Streptococcus suis 2 (SS2) by intramuscular injection. The pigs died consecutively within 72 h after the challenge. An additional five non-infected pigs were euthanised and used as controls. Microstructural observations showed that degeneration, bleeding, congestion, cellular necrosis, and an increase in inflammatory cells were present in all organs and tissues except the brain. Ultrastructural observations revealed mitochondrial vacuolation and malformed or missing cristae, indicating that infection of minipigs with strain SH08 of SS2 can lead to extensive lesions in major internal organs and tissues. The findings also demonstrated that the minipig is a useful model for the study of SS2 infection.

分类号: S85

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