Structural Characteristics of the Novel Polysaccharide FVPA1 from Winter Culinary-Medicinal Mushroom, Flammulina velutipes (Agaricomycetes), Capable of Enhancing Natural Killer Cell Activity against K562 Tumor Cells

文献类型: 外文期刊

第一作者: Jia, Wei

作者: Jia, Wei;Feng, Jie;Zhang, Jing-Song;Lin, Chi-Chung;Wang, Wen-Han;Jia, Wei;Feng, Jie;Zhang, Jing-Song;Lin, Chi-Chung;Wang, Wen-Han;Chen, Hong-Ge

作者机构:

关键词: Flammulina velutipes;FVPA1 polysaccharide;medicinal mushrooms;NK cell activity;NMR;structural characterization

期刊名称:INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS ( 影响因子:1.921; 五年影响因子:1.879 )

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收录情况: SCI

摘要: FVPA1, a novel polysaccharide, has been isolated from fruiting bodies of the culinary-medicinal mushroom Flammulina velutipes, a historically popular, widely cultivated and consumed functional food with an attractive taste, beneficial nutraceutical properties such as antitumor and immunomodulatory effects, and a number of essential biological activities. The average molecular weight was estimated to be similar to 1.8 x 10(4) Da based on high-performance size exclusion chromatography. Sugar analyses, methylation analyses, and 1H, C-13, and 2-dimensional nuclear magnetic resonance spectroscopy revealed the following structure of the repeating units of the FVPA1 polysaccharide Identification of this structure would conceivably lead to better understanding of the nutraceutical functions of this very important edible fungus. Bioactivity tests in vitro indicated that FVPA1 could significantly enhance natural killer cell activity against K562 tumor cells.

分类号: Q94

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