ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway

文献类型： 外文期刊

第一作者： Liu, Jia

作者： Liu, Jia;Ma, Leina;Chen, Xiao;Wang, Jianxun;Yu, Tao;Gong, Ying;Ma, Aiguo;Liang, Hui;Ma, Leina;Zheng, Lanhong

作者机构：

关键词： Oleanolic acid;Apoptosis;ERK;Nrf2

期刊名称：TUMOR BIOLOGY （ 影响因子：3.65； 五年影响因子：3.445 ）

ISSN： 1010-4283

年卷期： 2016 年 37 卷 6 期

页码：

收录情况： SCI

摘要： Oleanolic acid (OA) is a natural triterpenoid that is widely distributed in edible and medicinal plants. OA exerts anti-tumor activity on a wide range of cancer cells primarily through inducing apoptosis. Dysregulated ERK signaling is closely complicated in the biology of cancer, such as metastasis, proliferation, and survival, and it can be activated by various stimuli. In this study, we found that OA induced the activation of ERK in cancer cells. ERK activation compromised the apoptosis induced by OA. Blocking ERK activation by U0126 or siRNAs was able to potentiate the pro-apoptotic activity of OA on cancer cells. OA was shown to promote ERK-dependent Nrf2 expression in cancer cells, and in turn, Nrf2 expression was able to suppress OA-induced ROS generation. Blockade of Nrf2 expression was able to increase ROS levels and apoptotic death in cancer cells. In conclusion, we provided evidences that ERK activation is a mechanism underlying the resistance of cancer cells to OA-induced apoptosis and targeting ERK is a promising strategy to enhance the anti-tumor efficacy of OA.

分类号：

  • 相关文献

[1]Delayed and persistent ERK1/2 activation is required for 4-hydroxytamoxifen-induced cell death. Zhou, Jian-Hua,Yu, David V.,Cheng, Jingwei,Shapiro, David J.. 2007

[2]p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid. Liu, Jia,Wu, Ning,Liu, Ge,Lin, Xiu-Kun,Zheng, Lan-Hong,Ma, Lei-Na,Liu, Ge,Lin, Xiu-Kun,Zhong, Jia-Teng. 2014

[3]Memory Impairment in Cognitively Impaired Aged Rats Associated With Decreased Hippocampal CREB Phosphorylation: Reversal by Procyanidins Extracted From the Lotus Seedpod. Xu, Jiqu,Rong, Shuang,Wu, Hailei,Bao, Wei,Wang, Di,Yao, Ping,Liu, Liegang,Xu, Jiqu,Deng, Qianchun,Huang, Fenghong,Rong, Shuang,Wu, Hailei,Bao, Wei,Wang, Di,Yao, Ping,Liu, Liegang,Xie, Bijun,Sun, Zhida. 2010

[4]TLR2 mediates autophagy through ERK signaling pathway in Mycoplasma gallisepticum-infected RAW264.7 cells. Lu, Ziyin,Xie, Daoyuan,Chen, Ying,Tian, Erjie,Muhammad, Ishfaq,Chen, Xueping,Miao, Yusong,Hu, Wanjun,Wu, Ziyong,Ni, Huili,Li, Jichang,Xin, Jiuqing,Li, Yuan.

[5]Mechanisms involved in ceramide-induced cell cycle arrest in human hepatocarcinoma cells. Wang, Jing,Lv, Xiao-Wen,Shi, Jie-Ping,Hu, Xiao-Song. 2007

[6]Regulation mechanism of oxidative stress induced by high glucose through PI3K/Akt/Nrf2 pathway in juvenile blunt snout bream (Megalobrama amblycephala). Pan, Wenjing,Huang, Xin,Ge, Xianping,Moosa, Silli Laban,Liu, Bo,Liang, Hualiang,Zhang, Wuxiao,Miao, Linghong,Lin, Yan,Ge, Xianping,Liu, Bo,Ren, Mingchun,Zhou, Qunlan,Pan, Liangkun. 2017

[7]Effects of diclofenac on the expression of Nrf2 and its downstream target genes in mosquito fish (Gambusia affinis). Bao, Shuang,Nie, Xiangping,Ou, Ruikang,Wang, Chao,Ku, Peijia,Li, Kaibing.

[8]Nobiletin and its colonic metabolites suppress colitis-associated colon carcinogenesis by down-regulating iNOS, inducing antioxidative enzymes and arresting cell cycle progression. Wu, Xian,Song, Mingyue,Gao, Zili,Sun, Yue,Wang, Minqi,Li, Fang,Zheng, Jinkai,Xiao, Hang,Sun, Yue,Zheng, Jinkai.

[9]Anti-inflammatory effects of 4 '-demethylnobiletin, a major metabolite of nobiletin. Wu, Xian,Song, Mingyue,Rakariyatham, Kanyasiri,Zheng, Jinkai,Guo, Shanshan,Xiao, Hang,Zheng, Jinkai,Guo, Shanshan,Tang, Zhonghai,Zhou, Shuangde,Xiao, Hang.

[10]Effects of equol on H2O2-induced oxidative stress in primary chicken intestinal epithelial cells. Lin, Xiajing,Jiang, Shouqun,Jiang, Zongyong,Zheng, Chuntian,Gou, Zhongyong.

[11]Zearalenone induces oxidative damage involving Keap1/Nrf2/HO-1 pathway in hepatic L02 cells. Wu, Kejia,Liu, Xin,Fang, Min,Gong, Zhiyong,Wu, Kejia,Liu, Xin,Fang, Min,Gong, Zhiyong,Wu, Yongning.

[12]Oleanolic acid inhibits proliferation and invasiveness of Kras-transformed cells via autophagy. Liu, Jia,Zheng, Lanhong,Liu, Jia,Wu, Ning,Liu, Ge,Lin, Xiukun,Ma, Leina,Wang, Bin,Zhao, Youguang,Lin, Xiukun.

[13]Oleanolic Acid Induces Metabolic Adaptation in Cancer Cells by Activating the AMP-Activated Protein Kinase Pathway. Liu, Jia,Wu, Ning,Liu, Ge,Lin, Xiukun,Zheng, Lanhong,Liu, Jia,Liu, Ge,Ma, Leina,Zhong, Jiateng,Lin, Xiukun.

[14]Oleanolic acid induces protective autophagy in cancer cells through the JNK and mTOR pathways. Liu, Jia,Wu, Ning,Liu, Ge,Lin, Xiukun,Zheng, Lanhong,Liu, Jia,Liu, Ge,Lin, Xiukun,Zhong, Jiateng.

[15]Profiling and identification of the metabolites of ginsenoside Ro in rat faeces and urine after oral administration. Wang, Jia,Xiao, Shengyuan,Wang, Jia,Zheng, Peihe,Zheng, Siwen,Wang, Yufang,Zhu, Yanzhu,Wang, Yingping,Xiao, Shengyuan,Zhou, Hua.

[16]Preparation and characterization of monodisperse molecularly imprinted polymers for the recognition and enrichment of oleanolic acid. Tang, Zonggui,Wang, Jing,Li, Hongmin,Ji, Yong,Wang, Guohong,Lu, Chunxia,Liu, Changbin,Liu, Changbin.

[17]Application of FTIR and Active Ingredients Quantitative Analysis on Quality Control of Dai Medicine Alstonia scholaris (L.) R. Br.. Yang Ni-na,Zhao Ying-hong,Yang Ni-na,Yang Chun-yong,Wang Yuan-zhong,Wang Yuan-zhong. 2017

[18]Distribution and expression characteristics of triterpenoids and OSC genes in white birch (Betula platyphylla suk.). Yin, Jing,Ren, Chun-Lin,Zhan, Ya-Guang,Li, Chun-Xiao,Qiu, Wei,Li, Xin-Yu,Xiao, Jia-Lei,Peng, Hong-Mei.

[19]The Caspase Pathway of Linoelaidic Acid (9t, 12t-C18:2)-Induced Apoptosis in Human Umbilical Vein Endothelial Cells. Bin, Qiu,Rao, Huan,Hu, Jiang-Ning,Liu, Rong,Fan, Ya-Wei,Li, Jing,Deng, Ze-Yuan,Zhong, Xianfeng,Bin, Qiu,Du, Fang-Ling. 2013

[20]Detection of DNA ladder during cotyledon senescence in cotton. Q.E. XIE,I.D. LIU,S.X. YU,R.F. WANG,Z.X. FAN,Y.G. WANG,F.F. SHEN.

作者其他论文 更多>>

微信小程序