The effect of taraxerol acetate extracted from dandelion on alleviating oxidative stress responses in vitro

文献类型： 外文期刊

第一作者： Lu, Jiaquan

作者： Lu, Jiaquan;Yi, Siying;Shang, Yafang;Yang, Shaohua;Wang, Shuna;Cui, Kai

作者机构：

关键词： Oxidative stress; TA; metabolomics; transcriptomics; pathway

期刊名称：FREE RADICAL RESEARCH （ 影响因子：2.9； 五年影响因子：3.6 ）

ISSN： 1071-5762

年卷期： 2024 年 58 卷 12 期

页码：

收录情况： SCI

摘要： Oxidative stress can be alleviated by antioxidants intakes. Taraxerol acetate (TA), a natural triterpenoid extracted from dandelions, may reduce the risk of metabolic disorders by regulating oxidative stress. In the study, we investigated the effects of TA in relieving oxidative stress in murine intestinal epithelial cells using multiomics techniques. Here, we found that TA activated the antioxidant defense system. Total antioxidant capacity (T-AOC) and Catalase (CAT) activity notably increased after TA treatment. Additionally, TA treatment effectively reduced the levels of lactate dehydrogenase (LDH) and malonaldehyde (MDA) and alleviated H2O2-induced oxidative stress. Furthermore, TA induced significant changes in the levels of 30 important metabolites. Specifically, it activated the complement and coagulation cascades, NF-kappa B and MAPK and glycerophospholipid pathways, resulting in altered transcript levels of related genes, such as Serpinb9e, SCD2, Hspa1b, and Hspa1a. Thus, the results demonstrated that TA potentially could promote health by alleviating H2O2-induced oxidative damage and provide valuable insights for its further development.

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