Structurally diverse oxygen-containing aromatic compounds with anti-inflammatory activity from Aspergillus sp. LY-1-2

文献类型： 外文期刊

第一作者： Wang, Chu-Qiao

作者： Wang, Chu-Qiao;Ji, Fei-Xiang;Feng, Dan;Peng, Xiao-Ping;Lou, Hong-Xiang;Li, Gang;Pan, Jinzhi;Luo, Qian;Yuan, Shuang-Zhi;Lou, Hong-Xiang;Yuan, Chao

作者机构：

关键词： Endophytic fungus; Aspergillus; aromatic compounds; isocoumarins; anti-inflammatory

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.2； 五年影响因子：2.3 ）

ISSN： 1478-6419

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Three isocoumarins, ascoisocoumarin A (1), embeurekol (2), and sclerotinin A (3), and five biosynthetically related derivatives, ascospinols A-C (4, 6, and 7), and talaflavuols C and B (5 and 8), together with twelve polyketides or terpenes (9-20) were isolated from the fungus Aspergillus sp. LY-1-2 inhabited in a sample of Cordyceps sp. Most of them belong to the family of oxygen-containing aromatic compounds and compounds 1, 4, 6, and 7 are previously undescribed compounds. Their planar structures were established by a combined spectroscopic analysis of HRESIMS and NMR, and their stereochemistry was determined by 13C NMR calculations with sorted training set (STS) protocol analysis, and ECD calculations. New compounds 1 and 6 displayed potential anti-inflammatory effects in lipopolysaccharide (LPS)-induced BV2 microglia cells.

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