Virus infection and sphingolipid metabolism

文献类型： 外文期刊

第一作者： Dai, Jun

作者： Dai, Jun;Feng, Yiyi;Liao, Ying;Tan, Lei;Sun, Yingjie;Song, Cuiping;Qiu, Xusheng;Ding, Chan;Ding, Chan;Feng, Yiyi

作者机构：

关键词： Virus; Sphingolipid; Endosomal escape; Sphingolipid rheostat; Serum biomarker

期刊名称：ANTIVIRAL RESEARCH （ 影响因子：4.5； 五年影响因子：5.0 ）

ISSN： 0166-3542

年卷期： 2024 年 228 卷

页码：

收录情况： SCI

摘要： Cellular sphingolipids have vital roles in human virus replication and spread as they are exploited by viruses for cell entry, membrane fusion, genome replication, assembly, budding, and propagation. Intracellular sphingolipid biosynthesis triggers conformational changes in viral receptors and facilitates endosomal escape. However, our current understanding of how sphingolipids precisely regulate viral replication is limited, and further research is required to comprehensively understand the relationships between viral replication and endogenous sphingolipid species. Emerging evidence now suggests that targeting and manipulating sphingolipid metabolism enzymes in host cells is a promising strategy to effectively combat viral infections. Additionally, serum sphingolipid species and concentrations could function as potential serum biomarkers to help monitor viral infection status in different patients. In this work, we comprehensively review the literature to clarify how viruses exploit host sphingolipid metabolism to accommodate viral replication and disrupt host innate immune responses. We also provide valuable insights on the development and use of antiviral drugs in this area.

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