Advances in engineering the production of the natural red pigment lycopene: A systematic review from a biotechnology perspective

文献类型： 外文期刊

第一作者： Wang, Ya-Hui

作者： Wang, Ya-Hui;Zhang, Rong-Rong;Liu, Hui;Zhuang, Jing;Xiong, Ai-Sheng;Yin, Yue;Tan, Guo-Fei;Wang, Guang-Long;Zhang, Jian;Zhang, Jian;Zhuang, Fei-Yun

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关键词： Lycopene; Metabolic pathway; Fermentation; Genetic engineering; Plants

期刊名称：JOURNAL OF ADVANCED RESEARCH （ 影响因子：10.7； 五年影响因子：11.4 ）

ISSN： 2090-1232

年卷期： 2023 年 46 卷

页码：

收录情况： SCI

摘要： Background: Lycopene is a natural red compound with potent antioxidant activity that can be utilized both as pigment and as a raw material in functional food, and so possesses good commercial prospects. The biosynthetic pathway has already been documented, which provides the foundation for lycopene production using biotechnology.Aim of review: Although lycopene production has begun to take shape, there is still an urgent need to alle-viate the yield of lycopene. Progress in this area can provide useful reference for metabolic engineering of lycopene production utilizing multiple approaches.Key scientific concepts of review: Using conventional microbial fermentation approaches, biotechnologists have enhanced the yield of lycopene by selecting suitable host strains, utilizing various additives, and optimizing culture conditions. With the development of modern biotechnology, genetic engineering, pro-tein engineering, and metabolic engineering have been applied for lycopene production. Extraction from natural plants is the main way for lycopene production at present. Based on the molecular mechanism of lycopene accumulation, the production of lycopene by plant bioreactor through genetic engineering has a good prospect. Here we summarized common strategies for optimizing lycopene production engineering from a biotechnology perspective, which are mainly carried out by microbial cultivation. We reviewed the challenges and limitations of this approach, summarized the critical aspects, and provided sugges-tions with the aim of potential future breakthroughs for lycopene production in plants.(c) 2023 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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