Rnf20deficiency in adipocyte impairs adipose tissue development and thermogenesis

文献类型： 外文期刊

第一作者： Liang, Xiaojuan

作者： Liang, Xiaojuan;Tao, Cong;Pan, Jianfei;Zhang, Lilan;Liu, Lulu;Zhao, Ying;Fan, Yiping;Liu, Jiali;Li, Kui;Wang, Yanfang;Liu, Lulu;Cao, Chunwei;Jin, Wanzhu;Li, Wei;Zhao, Jianguo;Zhang, Jin;Lam, Sin Man;Shui, Guanghou;Jin, Wanzhu;Li, Wei;Zhao, Jianguo;Wang, Yanfang

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关键词： RNF20; fat loss; adipose tissue development; thermogenesis

期刊名称：PROTEIN & CELL （ 影响因子：14.87； 五年影响因子：11.279 ）

ISSN： 1674-800X

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收录情况： SCI

摘要： RNF20, an E3 ligase critical for monoubiquitination of histone H2B at lysine 120 (H2Bub), has been implicated in the regulation of various cellar processes; however, its physiological roles in adipocytes remain poorly characterized. Here, we report that the adipocyte-specific knockout ofRnf20(ASKO) in mice led to progressive fat loss, organomegaly and hyperinsulinemia. Despite signs of hyperinsulinemia, normal insulin sensitivity and improved glucose tolerance were observed in the young and aged CD-fed ASKO mice. In addition, high-fat diet-fed ASKO mice developed severe liver steatosis. Moreover, we observed that the ASKO mice were extremely sensitive to a cold environment due to decreased expression levels of brown adipose tissue (BAT) selective genes, including uncoupling protein 1 (Ucp1), and impaired mitochondrial functions. Significantly decreased levels of peroxisome proliferator-activated receptor gamma (Ppar gamma) were observed in the gonadal white adipose tissues (gWAT) from the ASKO mice, suggesting thatRnf20regulates adipogenesis, at least in part, throughPpar gamma. Rosiglitazone-treated ASKO mice exhibited increased fat mass compared to that of the non-treated ASKO mice. Collectively, our results illustrate the critical role of RNF20 in control of white and brown adipose tissue development and physiological function.

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