Comparative analysis of the pulmonary microbiome in healthy and diseased pigs

文献类型： 外文期刊

第一作者： Li, Zongjie

作者： Li, Zongjie;Wang, Xin;Di, Di;Pan, Ruyi;Gao, Yun;Xiao, Changguang;Li, Beibei;Wei, Jianchao;Liu, Ke;Qiu, Yafeng;Ma, Zhiyong

作者机构：

关键词： Porcine respiratory disease complex; Bronchoalveolar lavage fluid; Lung microbiota; Symbiotic microbiota; Microbial community

期刊名称：MOLECULAR GENETICS AND GENOMICS （ 影响因子：3.291； 五年影响因子：3.257 ）

ISSN： 1617-4615

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页码：

收录情况： SCI

摘要： The lungs possess an effective antimicrobial system and a strong ability to eliminate microorganisms in healthy organisms, and were once considered sterile. With the development of culture-independent sequencing technology, the richness and diversity of porcine lung microbiota have been gaining attention. In order to study the relationship between lung microbiota and porcine respiratory disease complex (PRDC), the lung microbiota in healthy and diseased swine bronchoalveolar lavage fluids were analyzed and compared using the Illumina MiSeq sequencing platform. The predominant microbial communities of healthy and diseased swine were similar at the phylum level, mainly composed of Proteobacteria, Firmicutes, Tenericutes, and Bacteroidetes. However, the bacterial taxonomic communities of healthy and diseased swine differed at the genus level. The higher relative abundances ofLactococcus,Enterococcus,Staphylococcus,andLactobacillusgenera in healthy swine might provide more benefits for lung health, while the enhanced richness ofStreptococcus,Haemophilus,Pasteurella,andBordetellagenera in diseased swine might be closely related to pathogen invasion and the occurrence of respiratory disease. In conclusion, the observed differences in the richness and diversity of lung microbiota can provide novel insights into their relationship with PRDC. Analyses of swine lung microbiota communities might produce an effective strategy for the control and prevention of respiratory tract infections.

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