Effects of CpG ODN on CD4(+) and CD8(+) T subpopulations in the immune response to porcine reproductive and respiratory syndrome killed virus vaccine

文献类型： 外文期刊

第一作者： Zhang, LH

作者： Zhang, LH;Tian, XS;Guo, Y;Zhou, FZ

作者机构：

关键词： CpG motifs;immune response;the newborn piglets;immunereinforcing agent;porcine reproductive and respiratory syndrome killed virus vaccine

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

ISSN： 0264-410X

年卷期： 2006 年 24 卷 11 期

页码：

收录情况： SCI

摘要： CpG ODN is a noval immumostimulatory reagent In this research, the effects of immunostimulatory CpG oligodeoxynucleotides (CpG ODN) on CD4(+) and CD8(+) T lymphocytes subpopulations in the newborn piglets blood were tested at different time with porcine reproductive and respiratory syndrome killed virus vaccine (PRRS vaccine) with or without CpG ODN. The results suggested that, the CD4(+)/CD8(+) ratio decreased with age in piglets inoculated with vaccine alone or GpC ODN with vaccine or phosphate buffer saline (PBS), however, it was stable in piglets co-inoculated with CpG ODN and PRRS vaccine (p > 0.05), the use of CpG ODN can prevent effectively the reduction of the proportion of CD4(+) T lymphocytes. High titers of PRRS specific antibody can also be tested in the newborn piglets serum immunized MRS vaccine and CpG ODN (p < 0.05). (c) 2005 Elsevier Ltd. All rights reserved.

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