CpG oligodinucleotides induce strong humoral and cellular responses to swine streptococcic septicemia vaccine in piglets in vivo
文献类型: 外文期刊
第一作者: Zhang, LH
作者: Zhang, LH;Guo, Y;Tian, XS;Zhou, FZ
作者机构:
关键词: the piglets;swine streptococcic septicemia killed vaccine;CpG ODN;immune response
期刊名称:INTERNATIONAL IMMUNOPHARMACOLOGY ( 影响因子:4.932; 五年影响因子:4.624 )
ISSN: 1567-5769
年卷期: 2006 年 6 卷 3 期
页码:
收录情况: SCI
摘要: Oligodinucleotides containing CpG motifs (CpG ODN) are strong adjuvants for immune responses, particularly in mice, but data on humoral and cellular immune responses in piglets are scarce. In this report, using the swine streptococcus as model bacteria, CpG ODN was used as immunoadjuvants to enhance the immune responses of the piglets to swine streptococcic septicemia killed vaccine (SSSK vaccine). The fire of specific antibodies to SSSK vaccine, the proliferation of lymphocytes, SSSK-specific interferon-gamma(IFN-gamma) and IL-6, the expression of major histocompatibility complex class II (MHC-II) and CD14 of peripheral blood mononuclear cells (PBMCs) were examined to identify the immune responses of the piglets. The results were found that the above-mentioned immune responses of the piglets with CpG ODN were significantly stronger than standard immunization protocols. All these data suggested that immunostimulatory CpG ODN was promising immune enhancers for vaccination against SSSK vaccine. (c) 2005 Elsevier B.V. All rights reserved.
分类号:
- 相关文献
作者其他论文 更多>>
-
Effects of CpG ODN on CD4(+) and CD8(+) T subpopulations in the immune response to porcine reproductive and respiratory syndrome killed virus vaccine
作者:Zhang, LH;Tian, XS;Guo, Y;Zhou, FZ
关键词:CpG motifs;immune response;the newborn piglets;immunereinforcing agent;porcine reproductive and respiratory syndrome killed virus vaccine
-
Effect of transgenic expression of porcine interleukin-6 gene and CpG sequences on immune responses of newborn piglets inoculated with Pseudorabies attenuated vaccine
作者:Zhang, LH;Tian, XS;Guo, Y;Zhou, FZ;Meng, MJ
关键词:newborn piglets;pseudorabies attenuated vaccine;CpG motifs;immune response;interleukin-6
-
Simple total synthesis of juvenile honnone analogue - Isopropyl 11-methoxy-3,7,11-tirimethyl-2,4-dodecadienoate
作者:Zhu, XH;Jiang, HF;Tian, XS;Ran, XG
关键词:juvenile hormone analogue;isopropyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate;citronellal;Wittig-Homer reaction;total synthesis
-
Functional expression and characterization of Eehinococcus granulosus thioredoxin peroxidase suggests a role in protection against oxidative damage
作者:Li, J;Zhang, WB;Loukas, A;Lin, RY;Ito, A;Zhang, LH;Jones, M;McManus, DP
关键词:Echinococcus granulosus;thioredoxin peroxidase;thiol-dependent peroxidase activity;antioxidant;H2O2 tolerance;peroxiredoxin gene superfamily
-
Synthesis and application of aliphatic juvenile hormone analogs
作者:Zhu, XH;Jiang, HF;Tian, XS;Ran, XG
关键词:juvenoids;insect;synthesis;application
-
Bandunamide, a novel cyclopeptide from the streptomyces Griseovariabilis bandungensis
作者:Tian, XS;Xie, SD;Jiang, XB;Zhou, XM;Yang, LM;Xiao, DJ
关键词:streptomyces;Griseovariabilis bandungensis;Bandunamide;structure elucidation;anti-fungus
-
Seasonal abundance of the mirids, Lygus lucorum and Adelphocoris spp. (Hemiptera : Miridae) on Bt cotton in northern China
作者:Li, W;Feng, H;Guo, Y
关键词:transgenic Bt cotton;population dynamics;Lygus lucorum;Adelphocoris spp.;China