Licochalcone A Induces Ferroptosis in Hepatocellular Carcinoma via Reactive Oxygen Species Activated by the SLC7A11/GPX4 Pathway

文献类型： 外文期刊

第一作者： Zhang, Jin-Xin

作者： Zhang, Jin-Xin;Li, Xiao;Zhang, Jin-Xin;Xiao, Yan;Jin, Ning-Yi;Li, Xiao;Han, Ji-Cheng;Li, Yi-Quan;Zhu, Yi-Long;Li, Ya-Ru;Zhao, Ren-Shuang;Jin, Ning-Yi;Fang, Jin-Bo;Han, Ji-Cheng;Fang, Jin-Bo;Han, Ji-Cheng;Li, Xiao

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关键词： Licochalcone A; hepatocellular carcinoma; ferroptosis; ROS

期刊名称：INTEGRATIVE CANCER THERAPIES （ 影响因子：2.9； 五年影响因子：3.7 ）

ISSN： 1534-7354

年卷期： 2023 年 22 卷

页码：

收录情况： SCI

摘要： Liver cancer is a common malignant tumor, and its incidence is increasing yearly. Millions of people suffer from liver cancer annually, which has a serious impact on global public health security. Licochalcone A (Lico A), an important component of the traditional Chinese herb licorice, is a natural small molecule drug with multiple pharmacological activities. In this study, we evaluated the inhibitory effects of Lico A on hepatocellular carcinoma cell lines (HepG2 and Huh-7), and explored the inhibitory mechanism of Lico A on hepatocellular carcinoma. First, we evaluated the inhibitory effects of Lico A on hepatocellular carcinoma, and showed that Lico A significantly inhibited and killed HepG2 and Huh-7 cells in vivo and in vitro. Transcriptomic analysis showed that Lico A inhibited the expression of solute carrier family 7 member 11 (SLC7A11), which induced ferroptosis. We confirmed through in vivo and in vitro experiments that Lico A promoted ferroptosis in hepatocellular carcinoma cells by downregulating SLC7A11 expression, thereby inhibiting the glutathione (GSH)-glutathione peroxidase 4 (GPX4) pathway and inducing activation of reactive oxygen species (ROS). In this study, we suggest that Lico A is a potential SLC7A11 inhibitor that induces ferroptotic death in hepatocellular carcinoma cells, thereby providing a theoretical basis for the development of natural small molecule drugs against hepatocellular carcinoma.

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