您好，欢迎访问中国水产科学研究院 机构知识库！
中国水产科学研究院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

ToIκB and ToIKK genes from golden pompano (Trachinotus ovatus): Molecular characterization, expression, and association with tolerance to Streptococcus agalactiae infection

文献类型： 外文期刊

作者： Gao, Jie 1 ; Liu, Ming-Jian 2 ; Pan, Jin-Min 1 ; Guo, Hua-Yang 2 ; Liu, Bao-Suo 2 ; Zhu, Ke-Cheng 2 ; Zhang, Nan 2 ; Zhang, Dian-Chang 3 ;

作者机构： 1.Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Peoples R China

2.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Key Lab South China Sea Fishery Resources Exploita, Minist Agr & Rural Affairs, Guangzhou 510300, Guangdong, Peoples R China

3.Sanya Trop Fisheries Res Inst, Sanya 572018, Peoples R China

4.Guangdong Prov Engn Technol Res Ctr Marine Biol Se, Guangzhou, Guangdong Provi, Peoples R China

关键词： Golden pompano ( Trachinotus ovatus ); Streptococcus agalactiae; IKK gene; I kappa B gene; Gene expression; Bioinformatics analysis

期刊名称：DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY （ 影响因子：2.4； 五年影响因子：2.7 ）

ISSN： 0145-305X

年卷期： 2025 年 166 卷

页码：

收录情况： SCI

摘要： Effective disease management is crucial for sustainable aquaculture, particularly for economically important species like golden pompano (Trachinotus ovatus). Streptococcus agalactiae represents a major threat to this species, leading to severe health issues and significant economic losses. Understanding the immune mechanisms involved is essential to address this challenge. The I kappa B and IKK genes are known to be key regulators of immune responses, playing pivotal roles in modulating inflammatory pathways during infections. However, their specific roles in golden pompano immunity are not well characterized. In this study, we used bioinformatics analysis and tissue-specific expression profiling to investigate the roles of I kappa B and IKK genes in golden pompano during bacterial infection. The results demonstrated that ToIKK was significantly upregulated during the early stages of infection, indicating rapid immune activation, while ToI kappa B showed an initial decrease followed by recovery, suggesting its involvement in inflammation modulation. These genes were found to regulate the NF-kappa B signaling pathway, which is crucial for coordinating the immune response to bacterial infection. This research provides valuable insights into the molecular basis of golden pompano immune response against S. agalactiae, offering a foundation for developing targeted anti-infection strategies and improving disease resistance and health management practices in aquaculture.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：中国水产科学研究院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台