您好，欢迎访问广东省农业科学院 机构知识库！
广东省农业科学院机构知识库

全部

  • 全部
  • 标题
  • 学者
  • 机构
  • 关键词

Cancer Cell Inhibiting Sea Cucumber (Holothuria leucospilota) Protein as a Novel Anti-Cancer Drug

文献类型： 外文期刊

作者： Ru, Ruizhen 1 ; Guo, Yanzheng 1 ; Mao, Juanxuan 1 ; Yu, Zonghe 2 ; Huang, Wen 3 ; Cao, Xudong 4 ; Hu, Huijian 5 ; Meng, Minjie 1 ; Yuan, Lihong 1 ;

作者机构： 1.Guangdong Pharmaceut Univ, Sch Biosci & Biopharmaceut, Guangdong Prov Key Lab Biotechnol Drug Candidates, Guangzhou 510006, Peoples R China

2.South China Agr Univ, Coll Marine Sci, Guangzhou 510640, Peoples R China

3.Guangdong Acad Agr Sci, Fisheries Res Ctr, Key Lab Anim Nutr & Feed Sci South China, Minist Agr & Rural Affairs,Guangdong Key Lab Anim, Guangzhou 510640, Peoples R China

4.Univ Ottawa, Dept Chem & Biol Engn, Ottawa, ON 999040, Canada

5.Guangdong Acad Sci, Inst Zool, Guangzhou 510260, Peoples R China

关键词： sea cucumber protein; anti-cancer activity; targeted effects; cell apoptosis; cell migration; marine extractions

期刊名称：NUTRIENTS （ 影响因子：6.706； 五年影响因子：7.185 ）

ISSN：

年卷期： 2022 年 14 卷 4 期

页码：

收录情况： SCI

摘要： Cancer remains the primary cause of death worldwide. To develop less toxic anti-cancer drugs to relieve the suffering and improve the survival of cancer patients is the major focus in the anti-cancer field. To this end, marine creatures are being extensively studied for their anti-cancer effects, since extracts from at least 10% of the marine organisms have been shown to possess anti-tumor activities. As a classic Chinese traditional medicine, sea cucumbers and compounds extracted from the sea cucumbers, such as polysaccharides and saponins, have recently been shown to exhibit anti-cancer, anti-inflammatory, and anti-oxidant effects. Holothuria leucospilota (H. leucospilota) is a tropical edible sea cucumber species that has been successfully cultivated and farmed in large scales, providing a readily available source of raw materials to support the development of novel marine anti-cancer drugs. However, very few studies have so far been performed on the biological activities of H. leucospilota. In this study, we first investigated the anti-cancer effect of H. leucospilota protein on three cancer cell lines (i.e., HepG2, A549, Panc02) and three normal cell lines (NIH-3T3, HaCaT, 16HBE). Our data showed that H. leucospilota protein decreased the cell viabilities of HepG2, A549, HaCaT, 16HBE in a concentration-dependent manner, while Panc02 and NIH-3T3 in a time- and concentration-dependent manner. We also found that the inhibitory effect of H. leucospilota protein (>= 10 mu g/mL) on cell viability is near or even superior to EPI, a clinical chemotherapeutic agent. In addition, our data also demonstrated that H. leucospilota protein significantly affected the cell cycle and induced apoptosis in the three cancer cell lines investigated; in comparison, it showed no effects on the normal cell lines (i.e., NIH-3T3, HaCaT and 16HBE). Finally, our results also showed that H. leucospilota protein exhibited the excellent performance in inhibiting cell immigrations. In conclusion, H. leucospilota protein targeted the cancer cell cycles and induced cancer cell apoptosis; its superiority to inhibit cancer cell migration compared with EPI, shows the potential as a promising anti-cancer drug.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：广东省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台