Solubility-permeability interplay of a supersaturated lutein delivery system constructed by glycosylated stevioside and hydroxypropyl-methylcellulose
文献类型： 外文期刊
作者： Luo, Shuwei 1 ; Zhang, Yan 2 ; Song, Jiangfeng 1 ; Li, Ying 1 ; Wu, Caie 2 ; Zhang, Chenchen 3 ;
作者机构： 1.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing 210014, Peoples R China
2.Nanjing Forestry Univ, Coll Light Ind & Food Engn, Nanjing 210037, Peoples R China
3.Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang 212013, Peoples R China
关键词： Lutein; Supersaturated complex; Molecular dynamics simulation; Solubility; Permeability
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）
ISSN： 0141-8130
年卷期： 2024 年 258 卷
页码：
收录情况： SCI
摘要： This study investigated the solubilizing capacity of glycosylated stevioside/hydroxypropyl-methylcellulose (stevia-G-HPMC) complexes with varying mass ratios on lutein. The impact on the steady-state flux and permeability coefficient of intracellular lutein was also explored through the construction of a Caco-2 cellular transport model. The results indicated that the equilibrium solubility of lutein linearly increased with an increase in stevia-G amount. The stability constants of the ternary system surpassed those of the binary system. Molecular dynamics simulation revealed a tight and stable structure in lutein supersaturated complexes. Meanwhile, lutein-stevia-G-HPMC complexes demonstrated superior cumulative penetrations, with the peak P-app (AP -> BL) value being (3.24 +/- 0.89) x 10(-5) cm.s(-1). There was a slight decrease in P-app (BL -> AP), which improved the forward transport of lutein. Highly soluble lutein in aqueous environments saturated the extracellular transport proteins on the AP side of cell membranes, thereby maintaining the high permeability transport. Notably, the permeability trend of lutein in Caco-2 cells negatively correlated with the equilibrium solubility and matched the single exponential growth model. When the mass ratio of lutein, stevia-G and HPMC was 1:21:5, the solubility-permeability trade-off of lutein was effectively maintained.
- 相关文献
作者其他论文 更多>>
-
Unraveling the key structural characteristics enhancing digestion resistance of wheat starch-mung bean hull polyphenols complexes
作者：Wang, Ziyin;Xu, Lujing;Teng, Cong;Chai, Zhi;Feng, Jin;Lu, Yifei;Hu, Xindi;Ma, Kaiyang;Li, Ying;Wang, Ziyin;Li, Ying;Yuan, Xingxing;Chen, Xin
关键词：Wheat starch; Mung bean hull polyphenols; Molecular interaction; Multi-scale structure; Digestibility
-
Estimation of Processing Tomato Nutrient Uptake Based on the QUEFTS Model in Xinjiang
作者：Yibati, Halihashi;Gao, Jie;Yibati, Halihashi;Zhang, Yan;Li, Qingjun;Xu, Xinpeng;He, Ping;Yin, Xinhua
关键词：processing tomato; fruit yield; QUEFTS model; nutrient; internal efficiency (IE)
-
Sodium alginate coated ferritin as ACE inhibitory peptide carrier: Prolonged release property and enhanced transepithelial transport
作者：Li, Ying;Wang, Ziyin;Xia, Weirong;Chai, Zhi;Feng, Jin;Teng, Cong;Ma, Kaiyang;Hu, Xindi;Xu, Lujing;Li, Ying;Wang, Ziyin
关键词：Ferritin; Sodium alginate; AHLL; Simulated digestion; Transepithelial transport
-
Evaluation of different breeding waste compost applications on lettuce cultivation: growth, quality, mineral elements, and heavy metals accumulation
作者：Meng, Lili;Kamaruddin, Mohamad Anuar;Meng, Lili;Meng, Lili;Song, Jiangfeng;Yusoff, Mohd Suffian
关键词：Breeding waste compost; growth; heavy metals; lettuce; mineral elements; quality
-
Hyaluronic acid-decorated lipid nanocarriers as novel vehicles for curcumin: Improved stability, cellular absorption, and anti-inflammatory effects
作者：Feng, Jin;Wang, Zhen;Huang, Wuyang;Zhao, Xingyu;Xu, Lujing;Teng, Cong;Li, Ying;Wang, Zhen;Zhao, Xingyu
关键词：Nanostructured lipid carriers; Hyaluronic acid; Curcumin; Oral delivery; Receptor-mediated endocytosis; Anti-inflammatory capacity
-
Effect of Different Harvest Time and Microwave Aging on Aroma Characteristics of Japanese Apricot Wine
作者：Li, Aoting;Wang, Yike;Huang, Xiao;Segbo, Silas;Gao, Zhihong;Song, Jiangfeng
关键词：Japanese apricot; steeped mume wine; aroma component; nutritional quality; microwave aging
-
Cold plasma reengineers peanut protein isolate: Unveiling changes in functionality, rheology, and structure
作者：Nasiru, Mustapha Muhammad;Feng, Jin;Song, Jiangfeng;Li, Chunyang;Boateng, Evans Frimpong;Alnadari, Fawze;Bako, Hadiza Kabir;Ibeogu, Henry Isaiah;Yan, Wenjing;Zhang, Jianhao;Liu, Huan;Zhang, Qingqiang;Masisi, Kabo;Roth, Chuon Mony;Zhang, Jianhao
关键词：Peanut protein isolate; Cold plasma; Rheology; Functional properties; Structural properties
