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Untargeted LC-MS metabolomics reveals the metabolic responses in the Eriocheir sinensis gills exposed to salinity and alkalinity stress

文献类型： 外文期刊

作者： Wang, Shihui 1 ; Song, Yingying 1 ; Luo, Liang 1 ; Zhang, Rui 1 ; Guo, Kun 1 ; Zhao, Zhigang 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Heilongjiang River Fisheries Res Inst, Key Open Lab Cold Water Fish Germplasm Resources &, Harbin 150070, Peoples R China

2.Chinese Acad Fishery Sci, Engn Technol Res Ctr Saline Alkaline Water Fisheri, Harbin 150070, Peoples R China

3.Northeast Agr Univ, Coll Anim Sci & Technol, Harbin 150030, Peoples R China

4.Chinese Acad Fishery Sci, Heilongjiang Fisheries Res Inst, 232 Hesong St, Harbin 150070, Heilongjiang, Peoples R China

关键词： Eriocheir sinensis; Saline-alkaline; Fatten; Metabolomics

期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY （ 影响因子：3.9； 五年影响因子：3.8 ）

ISSN： 1532-0456

年卷期： 2024 年 281 卷

页码：

收录情况： SCI

摘要： In recent years, saline-alkaline aquaculture development has become an important measure for China to expand its fishery development space to ensure food safety. Previous studies have verified that salinity and alkalinity positively influence the quality of Chinese mitten crabs (Eriocheir sinensis). However, the regulatory mechanism of E. sinensis endures saline-alkaline stress which remains obscure. This study investigated the metabolic changes in puberty-molting E. sinensis gills exposed to freshwater (FW), sodium chloride salinity of 5 ppt (SW), and carbonate alkalinity 10.00 mmol/L (AW) for 50 days using untargeted liquid chromatography-mass spectrometry metabolomics (LC-MS). A total of 5802 (positive-ion mode) and 6520 (negative-ion mode) peaks were extracted by LC-MS, respectively. A total of 188 (50 upregulated and 138 downregulated), 141 (94 upregulated and 47 downregulated), and 130 (87 upregulated and 43 downregulated) significantly regulated metabolites (SRMs) were observed in the FW-SW, FW-AW, and SW-AW treatments, respectively, wherein 42 generic SRMs were also found by Venn diagram analysis. Seven of the top 10 SRMs with the highest (variable importance in projection) VIP values were similarly identified in FW-SW and SW-AW. Integrated analysis of key metabolic pathways revealed glycerophospholipid, choline in cancer, phenylalanine, and butanoate metabolism. Overall, significant differences were observed in the metabolites and key metabolic pathways of E. sinensis gill exposed to salinity and alkalinity stress. These results will be helpful in understanding the environmental adaptability of aquatic crustaceans to saline-alkaline water.

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