Vitamin D3 promotes fish oocyte development by directly regulating gonadal steroid hormone synthesis
文献类型： 外文期刊
作者： Yang, Gang 1 ; Cheng, Ke 1 ; Huang, Yanqing 2 ; Wang, Chunfang 1 ;
作者机构： 1.Huazhong Agr Univ, Coll Fisheries, Dept Fishery Resources & Environm, Shizishan Rd, Wuhan 430070, Peoples R China
2.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Dept Aquaculture Technol, Shanghai 200090, Peoples R China
关键词： vitamin D-3; vitellogenin synthesis; ovarian development; reproduction; zebrafish
期刊名称：BIOLOGY OF REPRODUCTION （ 影响因子：3.6； 五年影响因子：4.2 ）
ISSN： 0006-3363
年卷期： 2024 年 110 卷 3 期
页码：
收录情况： SCI
摘要： Vitamin D receptors and vitamin D-3-metabolizing enzymes have been found to be highly expressed in the ovaries and spermatophores of fish. However, the role of vitamin D-3 on fish gonadal development has rarely been reported. In this study, 2-month-old female zebrafish were fed with different concentrations of vitamin D-3 diets (0, 700, 1400, and 11 200 IU/kg) to investigate the effects of vitamin D-3 on ovarian development. The diet with 0 IU/kg vitamin D-3 resulted in elevated interstitial spaces, follicular atresia, and reproductive toxicity in zebrafish ovaries. Supplementation with 700 and 1400 IU/kg of vitamin D-3 significantly increased the oocyte maturation rate; upregulated ovarian gonadal steroid hormone synthesis capacity; and elevated plasma estradiol, testosterone, and ovarian vitellogenin levels. Furthermore, the current study identified a vitamin D response element in the cyp19a1a promoter and demonstrated that 1.25(OH)(2)D-3-vitamin D response directly activated cyp19a1a production through activating the vitamin D response element. In conclusion, this study shows that an appropriate concentration of vitamin D-3 can promote zebrafish ovarian development and affect vitellogenin synthesis through the vdr/cyp19a1a/er/vtg gene axis.
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