Rutin Inhibits Histamine-Induced Cytotoxicity of Zebrafish Liver Cells via Enhancing Antioxidant and Anti-Inflammatory Properties
文献类型： 外文期刊
作者： Cheng, Ke 1 ; Liu, Apeng 3 ; Peng, Di 2 ; Dong, Lixue 2 ; Liu, Yangyang 2 ; Tian, Juan 2 ; Wen, Hua 2 ; Luo, Yongju 1 ; Guo, Zhongbao 1 ; Jiang, Ming 2 ;
作者机构： 1.Guangxi Acad Fishery Sci, China Guangxi ASEAN Key Lab Comprehens Exploitat &, Key Lab Aquaculture Genet & Breeding & Hlth Aquacu, Minist Agr & Rural Affairs, Nanning 530021, Peoples R China
2.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Wuhan 430223, Peoples R China
3.Shenzhen Aohua Grp Co Ltd, Shenzhen 518054, Peoples R China
关键词： rutin; histamine; Nrf2; NF-kappa B; zebrafish liver cells
期刊名称：FISHES （ 影响因子：2.4； 五年影响因子：2.4 ）
ISSN：
年卷期： 2025 年 10 卷 8 期
页码：
收录情况： SCI
摘要： Histamine can damage the antioxidant and immune systems in fish and crustaceans. Rutin, a natural substance with a diverse phenolic structure, has demonstrated antioxidant and anti-inflammatory properties. However, whether rutin can mitigate histamine-induced negative effects remains uninvestigated in fish models. This study investigated the effect of 0.1-100 mu M rutin preincubation on histamine (29.5 mM)-induced cytotoxicity in zebrafish liver cells (ZFL) and its potential mechanisms. Results showed that 0.1-100 mu M rutin significantly improved ZFL cell survival following histamine stimulation and protected cellular morphology. Rutin inhibited the adverse effects of histamine on ZFL by scavenging or suppressing the accumulation of reactive oxygen species (ROS), H2O2, and malondialdehyde (MDA), while increasing the activities of superoxide dismutase (SOD), catalase (CAT), and total antioxidant capacity (T-AOC). At the protein level, 10 mu M rutin significantly promoted Nrf2 protein expression. HO-1 protein was significantly up-regulated after preincubation with 0.1-10 mu M rutin, whereas IL-1 beta protein levels were significantly down-regulated. The mechanism may involve activation of the Nrf2 antioxidant signaling pathway and inhibition of the NF-kappa B inflammatory signaling pathway. In summary, within the experimental concentration range, 10 mu M rutin showed the strongest inhibitory effects on histamine-induced ZFL cell death and oxidative stress. This study provides a theoretical basis and data support for evaluating rutin's feasibility as a green aquatic feed additive.
- 相关文献
作者其他论文 更多>>
-
Effects of Temporary Rearing on the Muscle Flavor Quality of Chinemys reevesii
作者：Lu, Xiaorong;Yu, Yali;Dong, Lixue;Zhang, Lang;Mao, Tao;Zhou, Yuntao;He, Li;Lu, Xiaorong;He, Gang;Liu, Yun
关键词：
Chinemys reevesii -
The long-term effect of non-invasive sampling on the genetic diversity and growth performance of cultured Gymnocypris chilianensis (Cyprinidae) population: an evaluation based on 70 days
作者：Liu, Biyuan;Cheng, Qiqun;Peng, Di;Song, Dan;Liu, Biyuan;Song, Dan;Lou, Zhongyu;Qin, Yong
关键词：Non-invasive sampling; Gymnocypris chilianensis; molecular marker; Genetic diversity; growth performance
-
Mechanisms of hepatic dysfunction in Nile tilapia (Oreochromis niloticus) fed a high-fava bean (Vicia faba L.) diet
作者：Zhang, Xinyao;Zhang, Xinyao;Cheng, Ke;Dong, Lixue;Tian, Juan;Peng, Di;Zhang, Jianmin;Liu, Yangyang;Wen, Hua;Jiang, Ming;Zhu, Dexing;Li, Qingyong;Guo, Zhongbao;Luo, Yongju;Liu, Apeng
关键词：Tilapia; Fava bean; Muscle texture; Liver health; Metabolomics
-
Appropriate Fat Supplementation in High-Starch Diets Involved in the Modification of Fatty Acids Profile, Amino Acids Composition, and Antioxidant Capacity of Adult Nile Tilapia (Oreochromis niloticus) Muscle
作者：Zhang, Jianmin;Xie, Ningning;Jiang, Ming;Dong, Lixue;Wen, Hua;Tian, Juan
关键词：antioxidant capacity; fat level; flavor; high starch diet; nutritional value
-
Dietary Phaffia rhodozyma-Synthesized 3S, 3′S-Astaxanthin Promotes Body Coloration and Muscle Quality in Pacific White Shrimp Litopenaeus vannamei
作者：Zhang, Beili;Zhang, Chunyang;Xu, Jianing;Wang, Wenyi;Li, Chaoqun;Ma, Qinyuan;Zhang, Chengguo;Ma, Qinyuan;Tian, Juan
关键词：3S; 3 ' S-astaxanthin; body coloration;
Litopenaeus vannamei ; muscle quality; nutritional composition; texture -
Effects of lipid levels on growth performance and glucose and lipid metabolism of adult Nile tilapia ( Oreochromis niloticus) fed with high carbohydrate diets
作者：Xie, Ningning;Zhang, Jianmin;Jiang, Ming;Dong, Lixue;Lu, Xing;Wen, Hua;Tian, Juan;Meng, Xiaolin;Tian, Juan
关键词：Nile tilapia; High carbohydrate; Low lipid; Growth performance; Metabolic regulation
-
Effects of sodium butyrate on meat quality improvement and intestinal injury induced by high-level fava beans in Nile tilapia (Oreochromis niloticus)
作者：Qi, Haishen;Cheng, Ke;Dong, Lixue;Tian, Juan;Peng, Di;Wen, Hua;Liu, Mingdian;Jiang, Ming;Qi, Haishen;Yang, Ruibin;Guo, Zhongbao;Luo, Yongju
关键词：Nile tilapia; Fava bean; Sodium butyrate; Meat quality; Intestinal health
