Saikosaponin a ameliorates diet-induced fatty liver via regulating intestinal microbiota and bile acid profile in laying hens
文献类型： 外文期刊
作者： Feng, Jia 1 ; Ma, Hui 1 ; Yue, Yanrui 1 ; Wang, Lijun 1 ; Hao, Keyang 1 ; Zhang, Yanan 2 ; Li, Jinghe 3 ; Xiang, Yujun 3 ; Min, Yuna 1 ;
作者机构： 1.Northwest A&F Univ, Coll Anim Sci & Technol, Yangling 712100, Shaanxi, Peoples R China
2.Guangdong Acad Agr Sci, Inst Anim Sci,Minist Agr,State Key Lab Livestock, Key Lab Anim Nutr & Feed Sci South China, Guangdong Publ Lab Anim Breeding & Nutr,Guangdong, Guangzhou 510640, Peoples R China
3.Tongchuan City Hlth Supervis Inst, Tongchuan 629000, Shaanxi, Peoples R China
关键词： saikosaponin a; fatty liver; bile acid metabolism; gut microbiota; laying hen
期刊名称：POULTRY SCIENCE （ 影响因子：4.4； 五年影响因子：4.4 ）
ISSN： 0032-5791
年卷期： 2023 年 102 卷 12 期
页码：
收录情况： SCI
摘要： Fatty liver hemorrhagic syndrome is a widespread metabolic disease in laying hens that decreases egg production and even causes death in severe cases. Many traditional Chinese medicine ingredients, such as saikosaponin a (SSa), have been shown to alleviate fatty liver, but the underlying mechanisms remain unclear. In this study, we aimed to explore the alleviation of dietary SSa on excessive hepatic lipid deposition and the interactions between intestinal microbiota and bile acid (BA) in laying hens. Fifty-four 35-wk-old laying hens were randomly allocated into 3 treatment groups with 6 replicates (3 birds per replicate) and fed with a basal diet (CON), high-energy and low-protein diet (HELP), and HELP diet with 30 mg/kg SSa (HELP + SSa). SSa reversed diet-induced egg production rate decrease (P < 0.05). SSa could potently ameliorate HELP-induced accumulation of hepatic cholesterol and liver injury via the increase (P < 0.05) of mRNA expression of BA synthesis gene, such as cholesterol 7 alpha-hydroxylase 1. SSa treatment alleviated gut dysbiosis, especially reducing (P < 0.05) the relative abundance of bile salt hydrolase (BSH)-producing bacteria such as Lactobacillus, Bifidobacterium, and Turicibacter. Ileal BA metabolomic analysis revealed that SSa increased (P < 0.05) the content of tauro-conjugated BAs, mainly taurochenodeoxycholic acid and tauro-a-muricholic acid. The mRNA expression of farnesoid X receptor (FXR) and fibroblast growth factor 19 were decreased (P < 0.05) in intestine, which was associated with increased gene expression of enzymes in the BA synthesis that reduced the levels of cholesterol. Moreover, SSa treatment inhibited intestinal BA reabsorption via decreasing (P < 0.05) the mRNA expression of apical sodium-dependent bile acid transporter. Our findings indicated that SSa reduced liver cholesterol accumulation and alleviated fatty liver in laying hens through microbiota-BA-intestinal FXR crosstalk.
- 相关文献
作者其他论文 更多>>
-
Identification of key genes and pathways in duck fatty liver syndrome using gene set enrichment analysis
作者：Yang, Xue;Lin, Hao;Wang, Mengpan;Huang, Xuebing;Li, Kaichao;Xia, Weiguang;Zhang, Yanan;Wang, Shuang;Chen, Wei;Zheng, Chuntian;Lin, Hao;Wang, Mengpan
关键词：fatty liver syndrome; RNA-seq; GSEA; self-constructed gene set; duck
-
Nutritional Impacts of Dietary Selenium, Iodine and their Interaction on Egg Performance, and Antioxidant Profile in Laying Longyuan Duck Breeders
作者：Shang, Xiuguo;Sarker, Md Touhiduzzaman;Chen, Wei;Xu, Runsheng;Wang, Shuang;Xia, Weiguang;Zhang, Yanan;Jin, Chenglong;Wang, Shenglin;Zheng, Chuntian;Elokil, Abdelmotaleb;Sarker, Md Touhiduzzaman;Chen, Wei;Xu, Runsheng;Wang, Shuang;Xia, Weiguang;Zhang, Yanan;Jin, Chenglong;Wang, Shenglin;Zheng, Chuntian;Elokil, Abdelmotaleb;Elokil, Abdelmotaleb;Elokil, Abdelmotaleb
关键词：Selenium; Iodine; Production performance; Antioxidant gene expression; Longyuan breeder ducks
-
The impact of Bacillus subtilis DSM32315 and L-Threonine supplementation on the amino acid composition of eggs and early post-hatch performance of ducklings
作者：Azzam, Mahmoud Mostafa;Chen, Wei;Xia, Weiguang;Wang, Shuang;Zhang, Yanan;El-Senousey, HebatAllah Kasem;Zheng, Chuntian;El-Senousey, HebatAllah Kasem
关键词：ducks; Threonine; Bacillus subtilis; amino acid composition of eggs; hatch weight of ducklings
-
Dietary supplementation with 2-hydroxy-4-methyl(thio) butanoic acid and DL-methionine improves productive performance, egg quality and redox status of commercial laying ducks
作者：Zhang, Yanan;Zhuang, Zhiwei;Jin, Yongyan;Huang, Xuebing;Li, Kaichao;Wang, Shuang;Xia, Weiguang;Wang, Shenglin;Yu, Miao;Chen, Wei;Zheng, Chuntian;Mahmood, Tahir;Mercier, Yves;Mahmood, Tahir;Mercier, Yves
关键词：DL-Methionine; 2-Hydroxy-4 methyl(thio) butanoic acid; Productive performance; Ef ficacy; Laying duck
-
Dietary zinc supplementation affects eggshell quality and ultrastructure in commercial laying ducks by influencing calcium metabolism
作者：Zhang, Yanan;Deng, Yuanzhong;Jin, Yongyan;Zhuang, Zhiwei;Huang, Xuebing;Li, Kaichao;Wang, Shuang;Xia, Weiguang;Ruan, Dong;Wang, Shenglin;Zheng, Chuntian;Chen, Wei
关键词：zinc; mechanical property and ultrastructure; calcium metabolism; duck eggshell
-
Age-related changes in eggshell physical properties, ultrastructure, calcium metabolism-related serum indices, and gene expression in eggshell gland during eggshell formation in commercial laying ducks
作者：Zhang, Yanan;Deng, Yuanzhong;Jin, Yongyan;Wang, Shuang;Huang, Xuebing;Li, Kaichao;Xia, Weiguang;Ruan, Dong;Wang, Shenglin;Chen, Wei;Zheng, Chuntian
关键词：mechanical property; shell ultrastructure; laying duck; peak and late laying phase
-
Genetic context diversity of plasmid-borne bla(CTX-M-55) in Escherichia coli isolated from waterfowl
作者：Zhang, Yanan;Peng, Shan;Xu, Jinge;Pu, Ling;Han, Xue;Feng, Yulong;Li, Yafei;Zhang, Yanan
关键词：bla(CTX-M-55); IncFII-N; Cointegration; IS26; E. coli
