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Translation, ribosome biogenesis, and oxidative damage caused by chlorpyrifos exposure to common carp (Cyprinus carpio L.) liver: application of combined RNA-seq with sRNA-seq in risk evaluation of environmental toxicant chlorpyrifos

文献类型： 外文期刊

作者： Fu, Jing 1 ; Wang, Minghui 3 ; Chaudhry, Maria T. 4 ; Xue, Hongfei 5 ; Zhang, Lichun 6 ; Huang, Yanhua 1 ; Liu, Chunpe 1 ;

作者机构： 1.Zhongkai Univ Agr & Engn, Innovat Inst Anim Hlth Breeding, Guangzhou 510225, Peoples R China

2.Zhongkai Univ Agr & Engn, Coll Anim Sci & Technol, 501 Zhongkai Rd, Guangzhou, Peoples R China

3.Cornell Univ, Inst Biotechnol, Bioinformat Facil, Ithaca, NY 14853 USA

4.Bahauddin Zakariya Univ, Fac Vet Sci, Multan 60800, Pakistan

5.Northeast Agr Univ, Coll Anim Sci & Technol, Harbin 150030, Peoples R China

6.Jilin Acad Agr Sci JAAS, Inst Anim Biotechnol, Jilin 136100, Jilin, Peoples R China

关键词： Environmental pollutant; Chlorpyrifos; Carp liver; miRNA and sRNA; Risk evaluation

期刊名称：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH （ 影响因子：4.223； 五年影响因子：4.306 ）

ISSN： 0944-1344

年卷期： 2021 年 28 卷 40 期

页码：

收录情况： SCI

摘要： Pesticide chlorpyrifos (CPF) is a widespread environmental pollutant gaining attention as it is highly injurious to aquatic life. Although the toxicity of CPF is well characterized, but the mechanism of toxic response especially, the hepatotoxicity remained unclear. In this study, we performed integrated analysis, including micro-RNA (miRNA) and small RNA (sRNA) to analyze CPF exposure responding genes and enrichment pathways. A total of 23,742 expressed genes were detected and out of these expression levels of 1746 were changed significantly. Majority of them participated in protein biosynthesis, nucleotide binding, and oxidation-reduction activities. In extensive analysis of micro-RNA (miRNA) expression profiles by comparing CPF treated carp with control, we identified 214 novel miRNAs with CPM > 5 in at least one sample. The miRNAs have the same change in direction compared with overlapped mRNA pairs in upregulated genes, suggesting potential positive correlation. As a whole, we detected many differently expressed genes (DEGs) and miRNAs, which may be used as the biomarkers for the detection of CPF pollution in water and aquatic product safety. However, their functions are required to be deeply analyzed, especially more samples or time pointed data are needed to illustrate their concrete mechanism.

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