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Ethanolic extract of root from Arctium lappa L ameliorates obesity and hepatic steatosis in rats by regulating the AMPK/ACC/CPT-1 pathway

文献类型： 外文期刊

作者： Ma, Kaiyang 1 ; Sheng, Weixi 2 ; Gao, Rong 3 ; Feng, Jin 1 ; Huang, Wuyang 1 ; Cui, Li 1 ; Liu, Jun 4 ; Li, Ying 1 ;

作者机构： 1.Jiangsu Acad Agr Sci, Inst Agroprod Proc, Nanjing, Peoples R China

2.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Peoples R China

3.Nanjing Med Univ, Sch Publ Hlth, Nanjing, Peoples R China

4.Yangzhou Univ, Coll Food Sci & Engn, Yangzhou 210095, Jiangsu, Peoples R China

关键词： AMPK; Arctium lappa L; fatty acid beta-oxidation; metabolic-associated fatty liver disease; obesity; steatosis

期刊名称：JOURNAL OF FOOD BIOCHEMISTRY （ 影响因子：3.654； 五年影响因子：3.271 ）

ISSN： 0145-8884

年卷期：

页码：

收录情况： SCI

摘要： Burdock (Arctium lappa L) root is eaten as a vegetable in many countries and used as an ethnomedicine because of its various pharmacological effects. The objective of this study was to investigate the underlying mechanisms of ethanolic extract of root from Arctium lappa L root (ALE) to lose weight and regulate lipid metabolism. The results showed that ALE can regulate lipid metabolism level and inhibit the weight gain of rats induced by the high-sugar and high-fat diet. The contents of triglyceride and cholesterol in the liver of obese rats significantly reduced, and hepatic steatosis was ameliorated. In addition, this study identified that ALE enhanced hepatic fatty acid beta-oxidation and ameliorated hepatic steatosis by activating AMPK/ACC/CPT-1 pathway. These results indicated that ALE has a potential preventive and therapeutic effect on metabolic-associated fatty liver disease and obesity.

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