Isolation and genetic analysis of a novel triple-reassortant H1N1 influenza virus from a pig in China
文献类型： 外文期刊
作者： Xu, Min 1 ; Huang, Yuan 1 ; Chen, Jing 1 ; Huang, Zhong 1 ; Zhang, Jianfei 1 ; Zhu, Yanqiu 2 ; Xie, Shouyu 1 ; Chen, Qinl 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Vet Med Inst, Vet Publ Hlth Publ Lab Guangdong, Div Zoonoses, Guangzhou 510640, Peoples R China
2.Ctr Anim Dis Control & Prevent Dongguan, Dongguan 523086, Peoples R China
3.Anim Vaccine Supply Stn Guangdong, Guangzhou 510520, Guangdong, Peoples R China
关键词： Arctic charr
期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）
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年卷期：
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收录情况： SCI
摘要： Influenza A viruses of subtype H1N1 have been reported widely in pigs in China, associated with clinical disease. These mainly include classical swine H1N1, avian-like HIM, and human-like H1N1 viruses. In this study, we reported a novel triple-reassortant H1N1 virus (A/swine/Guangdong/1/2010) containing genes from the classical swine (NP, NS), human (PB1) and avian (HA, NA, M, PB2, PA) lineages, which was for the first time reported in China. Also. phylogenetic analysis further confirmed that five genes segments (NS, NP, PB2, PB1, PA) of the isolate were closely related to the novel reassortant H1N2 viruses isolated in China in 2006, while the other three (HA, NA, M) were closely related to avian-like H1N1 viruses in China. The isolation of triple-reassortant H1N1 influenza virus provides further evidence that pigs serve as emergence hosts or "mixing vessels", and swine influenza virus (SIV) surveillance in China should be given a high priority
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