Deoxynivalenol: Emerging Toxic Mechanisms and Control Strategies, Current and Future Perspectives
文献类型： 外文期刊
作者： Deng, Ying 1 ; You, Li 3 ; Wang, Xu 4 ; Wu, Wenda 5 ; Kuca, Kamil 6 ; Wu, Qinghua 1 ; Wei, Wei 2 ;
作者机构： 1.Yangtze Univ, Coll Life Sci, Jingzhou 434025, Peoples R China
2.Zhejiang Acad Agr Sci, State Key Lab Managing Biot & Chem Threats Qual &, Key Lab Traceabil Agr Genet Modified Organisms, Minist Agr & Rural Affairs, Hangzhou 310021, Peoples R China
3.Chongqing Coll Int Business & Econ, Coll Phys Educ & Hlth, Chongqing 401520, Peoples R China
4.Huazhong Agr Univ HZAU, Natl Reference Lab Vet Drug Residues, MAO Key Lab Detect Vet Drug Residues, Wuhan 430070, Hubei, Peoples R China
5.Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230009, Peoples R China
6.Univ Hradec Kralove, Fac Sci, Dept Chem, Hradec Kralove 50003, Czech Republic
7.Univ Granada, Andalusian Res Inst Data Sci & Computat Intelligen, Granada 18071, Spain
关键词： deoxynivalenol; lncRNA; miRNA; Wnt/beta-catenin; brain-gut axis; biodegradation
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.1； 五年影响因子：6.3 ）
ISSN： 0021-8561
年卷期： 2023 年 71 卷 29 期
页码：
收录情况： SCI
摘要： Deoxynivalenol (DON) is the most frequently present mycotoxin contaminant in food and feed, causing a variety of toxic effects in humans and animals. Currently, a series of mechanisms involved in DON toxicity have been identified. In addition to the activation of oxidative stress and the MAPK signaling pathway, DON can activate hypoxia-inducible factor-1 alpha, which further regulates reactive oxygen species production and cancer cell apoptosis. Noncoding RNA and signaling pathways including Wnt/beta-catenin, FOXO, and TLR4/NF-kappa B also participate in DON toxicity. The intestinal microbiota and the brain-gut axis play a crucial role in DON-induced growth inhibition. In view of the synergistic toxic effect of DON and other mycotoxins, strategies to detect DON and control it biologically and the development of enzymes for the biodegradation of various mycotoxins and their introduction in the market are the current and future research hotspots.
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