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Whole genome sequencing of a multidrug-resistant Bacillus thuringiensis HM-311 obtained from the Radiation and Heavy metal-polluted soil

文献类型： 外文期刊

作者： Zuo, Wenlu 1 ; Li, Jingchen 1 ; Zheng, Jie 1 ; Zhang, Lei 1 ; Yang, Qi 1 ; Yu, Yadong 1 ; Zhang, Zhidong 3 ; Ding, Qingqing 4 ;

作者机构： 1.Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, Nanjing 211800, Peoples R China

2.Nanjing Normal Univ, Sch Food Sci & Pharmaceut Engn, Nanjing 210023, Peoples R China

3.Xinjiang Acad Agr Sci, Inst Microbiol, Urumqi, Xinjiang Uigur, Peoples R China

4.Nanjing Med Univ, Affiliated Hosp 1, Jiangsu Prov Hosp, Dept Geriatr Oncol, Nanjing 210029, Peoples R China

关键词： Bacillus thuringiensis; Antibiotics resistance; Heavy metal tolerance; Virulence factor

期刊名称：JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE （ 影响因子：4.6； 五年影响因子：4.1 ）

ISSN： 2213-7165

年卷期： 2020 年 21 卷

页码：

收录情况： SCI

摘要： Objectives: Bacillus thuringiensis (BT) is distributed widely in the environment and utilised frequently for its highly specific toxins to target insect. However, BT is potentially pathogenic due to the high similarity between BT and Bacillus anthracis (BA). Meanwhile, there are reports that heavy metal pressure can promote the proliferation of antibiotic resistance in microorganisms through the co-selection of metal resistance genes (MRGs) and antibiotic resistance genes (ARGs). The aim of this work was revealed the MRGs and ARGs in a novel heavy metal tolerant and drug-resistant strain - B. thuringiensis HM-311, which was isolated from radiation and heavy metal-contaminated soil in Xinjiang (China). Methods: The genome of B. thuringiensis HM-311 was sequenced using a PacBio RS II platform and Illumina HiSeq 4000 platform at the Beijing Genomics Institute (BGI, Shenzhen, China). Results: The total size of B. thuringiensis HM-311 genome was 6,019,481 bp with a GC content of 35.85%. 134 genes related to antibiotics resistance and 75 genes related to heavy metal resistance were predicted in the B. thuringiensis HM-311 genome, the main ARGs and MRGs were discussed. Moreover, 30 verified virulence factor genes and 297 predicted virulence factor genes were annotated in the B. thuringiensis HM-311 genome. Conclusions: This genome can be used as a reference sequence for comparative genomic studies, elucidating antibiotic resistance development and the relationship between antibiotic resistance genes and heavy metal resistance genes in B. thuringiensis. (c) 2020 The Author(s). Published by Elsevier Ltd on behalf of International Society for Antimicrobial Chemotherapy.

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