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Deinococcus wulumuqiensis R12 synthesized silver nanoparticles with peroxidase-like activity for synergistic antibacterial application

文献类型： 外文期刊

作者： Liu, Jingjia 1 ; Zhang, Nan 1 ; Shen, Bowen 2 ; Zhang, Liling 3 ; Zhang, Zhidong 4 ; Zhu, Liying 1 ; Jiang, Ling 2 ;

作者机构： 1.Nanjing Tech Univ, Sch Chem & Mol Engn, Nanjing 210009, Peoples R China

2.Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, Nanjing, Peoples R China

3.Nanjing Tech Univ, Coll Food Sci & Light Ind, Nanjing, Peoples R China

4.Xinjiang Acad Agr Sci, Inst Microbiol, Xinjiang Key Lab Special Environm Microbiol, Urumqi, Peoples R China

关键词： AgNPs; antibacterial activity; combination therapy; Deinococcus wulumuqiensis R12; peroxidase-like activity; synergistic antibacterial activity

期刊名称：BIOTECHNOLOGY JOURNAL （ 影响因子：4.7； 五年影响因子：4.5 ）

ISSN： 1860-6768

年卷期： 2024 年 19 卷 4 期

页码：

收录情况： SCI

摘要： The use of a combination of several antibacterial agents for therapy holds great promise in reducing the dosage and side effects of these agents, improving their efficiency, and inducing potential synergistic therapeutic effects. Herein, this study provides an innovative antibacterial treatment strategy by synergistically combining R12-AgNPs with H2O2 therapy. R12-AgNPs were simply produced with the supernatant of an ionizing radiation-tolerant bacterium Deinococcus wulumuqiensis R12 by one-step under room temperature. In comparison with chemically synthesized AgNPs, the biosynthesized AgNPs presented fascinating antibacterial activity and peroxidase-like properties, which endowed it with the capability to catalyze the decomposition of H2O2 to generate hydroxyl radical. After the combination of R12-AgNPs and H2O2, an excellent synergistic bacteriostatic activity was observed for both Escherichia coli and Staphylococcus aureus, especially at low concentrations. In addition, in vitro cytotoxicity tests showed R12-AgNPs had good biocompatibility. Thus, this work presents a novel antibacterial agent that exhibits favorable synergistic antibacterial activity and low toxicity, without the use of antibiotics or a complicated synthesis process.

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