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Microbe-mediated synthesis of defect-rich CeO2 nanoparticles with oxidase-like activity for colorimetric detection of l-penicillamine and glutathione

文献类型： 外文期刊

作者： Zhang, Nan 1 ; Du, Yingyan 1 ; Zhang, Zhidong 4 ; Zhu, Liying 1 ; Jiang, Ling 2 ;

作者机构： 1.Nanjing Tech Univ, Sch Chem & Mol Engn, Nanjing 211816, Peoples R China

2.Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 211816, Peoples R China

3.Nanjing Tech Univ, Coll Food Sci & Light Ind, Nanjing 211816, Peoples R China

4.Xinjiang Acad Agr Sci, Inst Appl Microbiol, Xinjiang Key Lab Special Environm Microbiol, Urumqi 830091, Xinjiang, Peoples R China

期刊名称：NANOSCALE （ 影响因子：5.1； 五年影响因子：5.6 ）

ISSN： 2040-3364

年卷期： 2025 年 17 卷 7 期

页码：

收录情况： SCI

摘要： To enhance production efficiency, curtail costs, and minimize environmental impact, developing simple and sustainable nanozyme synthesis methods has been the focus of relevant research. In this report, graphite-coated CeO2 nanoparticles (CeO2 NPs) with multiple defects (Ce3+ defects, oxygen vacancies and carbon defects) were synthesized via the culture filtrate of the extremely radioresistant bacterium Deinococcus wulumuqiensis R12 (D. wulumuqiensis R12). The as-prepared CeO2 NPs exhibit remarkable oxidase (OXD)-like activity, efficiently catalyzing the oxidation of the chromogenic substrate 3,3 ',5,5 '-tetramethylbenzidine (TMB) to form oxTMB, even in the absence of H2O2. The electron-rich bioactive substances in the supernatant were demonstrated to modulate the electronic state of the Ce atom and played a key role in the formation of multiple defects, thereby enhancing the OXD-like activity of CeO2 NPs. Based on the inhibitory effect of sulphydryl groups (-SH) on the TMB-CeO2 system, a colorimetric strategy for the detection of both l-penicillamine (l-PA) and glutathione (GSH) was devised and successfully applied in real sample analysis. The linear ranges of l-PA and GSH detection were found to be 10-500 mu M and 9-200 mu M with the limits of detection (LODs) at 8.53 and 5.19 mu M, respectively. This work provides a straightforward, eco-friendly and nontoxic method for the synthesis and defect construction of CeO2 NPs with OXD-like activity.

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