文献类型： 外文期刊
作者： Ying, Youmin 1 ; Lei, Panyi 1 ; Xu, Yilian 1 ; Lin, Yuhao 1 ; Yang, Nini 1 ; Han, Yiwei 1 ; Zhang, Zhidong 3 ; Shan, Weiguang 1 ; Rao, Guiwei 2 ; Wang, Jianwei 1 ;
作者机构： 1.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
2.Zhejiang Shuren Univ, Interdisciplinary Res Acad, Hangzhou 310015, Peoples R China
3.Xinjiang Acad Agr Sci, Inst Microbiol, Xinjiang Lab Special Environm Microbiol, Urumqi 830091, Peoples R China
关键词： Fungal endophyte; Penicillium; Huperzia serrata; Sorbicillinoid; beta-Glucuronidase
期刊名称：FITOTERAPIA （ 影响因子：3.4； 五年影响因子：3.3 ）
ISSN： 0367-326X
年卷期： 2024 年 175 卷
页码：
收录情况： SCI
摘要： Three new sorbicillinoids sorbicatechols E-G (1-3), along with seven known compounds 4-10, were obtained from the ethanol extract of Penicillium sp. HS-11, a fungal endophyte of the medicinal plant Huperzia serrata. The structures of 1-3 were established by detailed interpretation of the spectroscopic data and their absolute configurations were established by comparative analyses of the ECD spectra. Sorbicatechol G (3) represented the first hybrid sorbicillinoid bearing a tetralone skeleton. In the in-vitro bioassay, trichodimerol (5) exhibited moderate inhibitory activity against the Escherichia coli beta-glucuronidase (EcGUS) with an IC50 value of 92.0 +/- 9.4 mu M.
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