PGC-1 alpha affects skeletal muscle and adipose tissue development by regulating mitochondrial biogenesis
文献类型： 外文期刊
作者： Kong, Shaofen 1 ; Cai, Bolin 1 ; Nie, Qinghua 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Lingnan Guangdong Lab Agr, State Key Lab Conservat & Utilizat Subtrop AgroBi, Guangzhou 510642, Guangdong, Peoples R China
2.Minist Agr, Guangdong Prov Key Lab AgroAnim Genom & Mol Bre, Guangzhou 510642, Guangdong, Peoples R China
3.Minist Agr, Key Lab Chicken Genet Breeding & Reprod, Guangzhou 510642, Guangdong, Peoples R China
关键词： PGC-1 alpha; Mitochondrial biogenesis; Skeletal muscle; Adipose tissue; Mitochondria
期刊名称：MOLECULAR GENETICS AND GENOMICS （ 影响因子：2.98； 五年影响因子：3.207 ）
ISSN： 1617-4615
年卷期： 2022 年 297 卷 3 期
页码：
收录情况： SCI
摘要： The discovery and interpretation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) protein in mitochondrial biogenesis, skeletal muscle and adipose tissue development has broad research prospects, so it is important to review the related studies of PGC-1 alpha in detail and comprehensively. PGC-1 alpha is a protein composed of 798 amino acids (aa) with a molecular weight of about 91 kDa. PGC-1 alpha is involved in the operation of the respiratory chain by combining with deacetylase and phosphorylase to bind some nuclear receptors. In addition, PGC-1 alpha affects skeletal muscle and adipose metabolism by regulating mitochondrial oxidative phosphorylation. Recently, new data suggest that regulating mitochondrial metabolism in adipose tissue may be an effective adjunct to the treatment of obesity. In addition, dietary resveratrol, which has an effective anti-obesity effect, has been shown to promote mitochondrial biosynthesis by activating AMPK/PGC-1 alpha axis, as well as to regenerate muscle damaged by obesity. In this review, we combined previous studies to explore the latest studies, showing that PGC-1 alpha can regulate mitochondrial biogenesis and is regulated by AMPK and SIRT1. Furthermore, PGC-1 alpha is a favored protein, which not only regulates muscle fiber type, inhibits muscle atrophy, but also participates in browning of white adipose tissue (WAT) and regulates body heat production. So, we concluded that PGC-1 alpha is a key gene in mitochondrial biogenesis and plays an important role in the regulation and regulation of mitochondrial biogenesis along with other genes involved in the process. Meanwhile, PGC-1 alpha acts as a core metabolic regulator in adipose tissue and skeletal muscle. This review comprehensively summarizes a large number of research findings. First, the role of PGC-1 alpha in mitochondrial biogenesis was clarified, and then the key role of PGC-1 alpha in the development of skeletal muscle and adipose tissue was reevaluated. Furthermore, the role of PGC-1 alpha in some human diseases was discussed. Finally, the role of PGC-1 alpha as a major gene in poultry was pointed out, and the future research direction was proposed.
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