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Integration of transcriptomic and metabolomic reveals carbonate alkalinity stress responses in the hepatopancreas of Litopenaeus vannamei

文献类型： 外文期刊

作者： Duan, Yafei 1 ; Xing, Yifu 1 ; Zhu, Xuanyi 1 ; Li, Hua 1 ; Wang, Yun 1 ; Nan, Yuxiu 1 ;

作者机构： 1.Chinese Acad Fishery Sci, South China Sea Fisheries Res Inst, Guangdong Prov Key Lab Fishery Ecol & Environm, Minist Agr & Rural Affairs,Key Lab South China Sea, Guangzhou 510300, Peoples R China

2.Sanya Trop Fisheries Res Inst, Key Lab Efficient Utilizat & Proc Marine Fishery R, Sanya 572018, Peoples R China

3.Chinese Acad Fishery Sci, Shenzhen Base South China Sea Fisheries Res Inst, Shenzhen 518121, Peoples R China

关键词： Shrimp; Alkalinity; Morphology; Gene transcription; Metabolites

期刊名称：AQUATIC TOXICOLOGY （ 影响因子：4.5； 五年影响因子：5.2 ）

ISSN： 0166-445X

年卷期： 2023 年 260 卷

页码：

收录情况： SCI

摘要： Carbonate alkalinity (CA) is one of the environmental factors affecting the survival and growth of aquatic ani-mals. However, the toxic effects of CA stress on Pacific white shrimp Litopenaeus vannamei at the molecular level are completely unclear. In this study, we investigated the changes of the survival and growth, and hepatopan-creas histology of L. vannamei under different levels of CA stress, and integrated transcriptomics and metab-olomics to explore major functional changes in the hepatopancreas and identify biomarkers. After CA exposure for 14 days, the survival and growth of the shrimp were reduced, and the hepatopancreas showed obvious histological damage. A total of 253 genes were differentially expressed in the three CA stress groups, and immune-related genes such as pattern recognition receptors, phenoloxidase system and detoxification meta-bolism were affected; substance transport-related regulators and transporters were mostly downregulated. Furthermore, the metabolic pattern of the shrimp was also altered by CA stress, especially amino acids, arach-idonic acid and B-vitamin metabolites. The integration analysis of differential metabolites and genes further showed that the functions of ABC transporters, protein digestion and absorption, and amino acid biosynthesis and metabolism were highly altered by CA stress. The results of this study revealed that CA stress caused im-mune, substance transport, and amino acid metabolic variations in L. vannamei, and identified several potential biomarkers related to stress response.

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